中青年与老年直肠癌患者的临床及病理表现比较

Comparative observation of clinical and pathological manifestations of rectal cancer between young and middle-aged and elderly patients

目的比较中青年与老年直肠癌患者的临床及病理表现。方法选取2016年1月至2018年12月于贵溪市人民医院收治的200例直肠癌患者作为研究对象,根据年龄分为中青年组(年龄30~59岁)与老年组(年龄≥60岁),每组100例。两组均开展直肠癌Dixon手术,并辅助化疗,比较两组初始症状、病理特征、生存情况。结果中青年组黏液脓血便、排便习惯改变发生率均高于老年组,腹部肿块、腹痛发生率均低于老年组,差异有统计学意义(P<0.05)。两组肿瘤位置、组织学分类、分化情况比较差异有统计学意义(P<0.05)。中青年组生存时间短于低于老年组,差异有统计学意义(P<0.05);两组3年生存率比较差异无统计学意义。结论中青年直肠癌患者病情发现较晚,初始症状与老年直肠癌患者差异较大,且中青年患者直肠癌生存时间较短。

Objective To compare the clinical and pathological manifestations of rectal cancer between young and middle-aged and elderly patients.Methods 200 patients with rectal cancer admitted to Guixi People's Hospital from January 2016 to December 2018 were selected as the research subjects,and they were divided into the young and middle-aged group(aged 30-59 years old)and the elderly group(aged≥60 years old)according to the age,with 100 cases in each group.Both groups underwent Dixon surgery for rectal cancer and adjuvant chemotherapy,the initial symptoms,pathological features and survival were compared between the two groups.Results The incidence of mucopurulent bloody stools and changes in bowel habits in the young and middle-aged group were higher than those in the elderly group,and the incidence of abdominal mass and abdominal pain were lower than those in the elderly group,and the differences were statistically significant(P<0.05).There were significant differences in tumor location,histological classification and differentiation between the two groups(P<0.05).The survival time in the young and middle-aged group was shorter than that in the elderly group,and the difference was statistically significant(P<0.05),there was no significant difference in 3-year survival rate between the two groups.Conclusion The condition of young and middle-aged patients with rectal cancer was found late,and the initial symptoms were different from those of elderly patients with rectal cancer,and the survival time of young and middle-aged patients with rectal cancer was shorter.