乌拉地尔与硝酸甘油联合硫酸镁治疗重度子痫前期疗效和安全性的对照研究

Comparative study on the efficacy and safety of urapidil and nitroglycerin combined with magnesium sulfate in the treatment of severe preeclampsia

目的探讨乌拉地尔与硝酸甘油联合硫酸镁治疗重度子痫前期患者的临床效果及安全性。方法选取2021年1月至2023年5月吉安市中心人民医院收治的58例重度子痫前期孕妇作为研究对象,随机分为对照组与治疗组,每组29例。对照组采用硝酸甘油联合硫酸镁治疗,治疗组采用乌拉地尔联合硫酸镁治疗,比较两组心率、血压、分娩方式、母体不良结局和围生儿不良事件发生情况、不良反应发生情况。结果治疗后,治疗组心率(heart rate,HR)、收缩压(systolic blood pressure,SBP)及舒张压(diastolic blood pressure,DBP)低于对照组,差异有统计学意义(P<0.05)。治疗组剖宫产率低于对照组,阴道分娩率高于对照组,差异有统计学意义(P<0.05)。治疗组母体不良结局发生率低于对照组,差异有统计学意义(P<0.05)。治疗组围生儿不良结局发生率低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论乌拉地尔联合硫酸镁治疗重度子痫前期患者疗效显著,能改善患者血压和心率,降低剖宫产率、母体不良结局和围生儿不良事件发生率,值得临床推广应用。

Objective To investigate the clinical efficacy and safety of urapidil and nitroglycerin combined with magnesium sulfate in the treat-ment of severe preeclampsia.Methods 58 pregnant women with severe preeclampsia admitted to Ji'an Central People's Hospital from January 2021 to May 2023 were selected as the study subjects,and they were randomly divided into the control group and the treatment group,with 29 cases in each group.The control group was treated with nitroglycerin combined with magnesium sulfate,and the treatment group was treated with urapidil combined with magnesium sulfate.The heart rate,blood pressure,delivery mode,maternal adverse outcomes,perinatal adverse events and adverse reactions were compared between the two groups.Results After treatment,heart rate(HR),systolic blood pressure(SBP)and diastolic blood pres-sure(DBP)in the treatment group were lower than those in the control group,and the difference was statistically significant(P<0.05).The cesarean section rate in the treatment group was lower than that in the control group,and the vaginal delivery rate was higher than that in the control group,the difference was statistically significant(P<0.05).The incidence of adverse outcomes in the treatment group was lower than that in the control group,and the differences were statistically significant(P<0.05).The incidence of perinatal adverse outcomes in the treatment group was lower than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion Urapdil combined with magnesium sulfate is effective in the treatment of severe preeclampsia,which can im-prove blood pressure and heart rate,reduce cesarean section rate,maternal adverse outcomes and perinatal adverse events,and is worthy of clinical promotion and application.