益气活血方联合脑苷肌肽注射液对脑梗死恢复期患者炎症因子水平与神经功能指标的影响

Effect of Yiqi Huoxue decoction combined with cattle encephalon glycoside and ignotin injection on inflammatory factors and neurological function indexes of patients with cerebral infarction in convalescence

目的探讨益气活血方联合脑苷肌肽注射液对脑梗死(cerebral infarction,CI)恢复期患者炎症因子水平与神经功能指标的影响。方法选取2021年1月至2022年4月宜春市第二人民医院收治的70例CI患者作为研究对象,随机分为对照组与观察组,每组35例。对照组采用脑苷肌肽注射液治疗,观察组在对照组基础上联合益气活血方治疗。比较两组炎症因子[白细胞介素-8(interleukin-8,IL-8)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)]水平、神经功能[美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)、神经元特异性烯醇化酶(neuron specific enolase,NSE)]、生命质量[生命质量综合评定问卷(generic quality of life inventory-74,GQOLI-74)]、血液学相关指标[基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)、超氧化物歧化酶(superoxide dismu-tase,SOD)和血清胱抑素C(cystatin C,Cys-C)]及临床疗效。结果治疗后,观察组TNF-α、IL-8水平均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组NIHSS评分、NSE水平均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组躯体功能、心理功能、物质生活、社会功能评分均高于对照组,差异有统计学意义(P<0.05);治疗后,观察组MMP-9、Cys-C水平均低于对照组,SOD水平高于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率为97.14%,高于对照组的74.29%,差异有统计学意义(P<0.05)。结论脑苷肌肽基础上联合益气活血方治疗CI效果显著,可改善患者神经功能,降低炎症因子水平,提高机体抗氧化能力,使患者回归正常生活状态。

Objective To explore the effect of Yiqi Huoxue decoction combined with cattle encephalon glycoside and ignotin injection on inflammatory factors and neurological function indexes of patients with cerebral infarction(CI)in convalescence.Methods A total of 70 patients with CI in convalescence admitted to the Yichun Second People's Hospital from January 2021 to April 2022 were selected as the research subjects,and they were randomly divided into the control group and the observation group,with 35 cases in each group.The control group was treated with cattle encephalon glycoside and ignotin injection,and the observation group was treated with Yiqi Huoxue decoction on the basis of the control group.The levels of inflammatory factors(interleukin-8[IL-8],tumor necrosis factor-α[TNF-α]),neurological function(National Institute of Health stroke scale[NIHSS],neuron specific enolase[NSE]),quality of life(generic quality of life inventory-74[GQOLI-74]),hematological related indicators(matrix metalloproteinase-9[MMP-9],superoxide dismutase[SOD]and serum cystatin C[Cys-C])and clinical efficacy were compared between the two groups.Results After treatment,the levels of TNF-αand IL-8 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05);after treatment,the scores of NIHSS and NSE level in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05);after treatment,the scores of physical function,psychological function,material life and social function in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05);after treatment,the levels of MMP-9 and Cys-C in the observation group were lower than those in the control group,and the level of SOD was higher than that in the control group,and the differences were statistically significant(P<0.05);the total effective rate of treatment in the observation group was 97.14%,which was higher than 74.29%in the control group,and the difference was statistically significant(P<0.05).Conclusion On the basis of cattle encephalon glycoside and ignotin,Yiqi Huoxue decoction has a significant effect on CI,which can improve the neurological function of patients,reduce the level of inflammatory factors,improve the antioxidant capacity of the body,and make patients return to normal life.