肝动脉灌注化疗栓塞治疗原发性肝癌的临床疗效及对患者血清指标与生命质量的影响

Clinical efficacy of hepatic artery perfusion chemoembolization in the treatment of primary liver cancer and its effect on patients'serum indexes and quality of life

目的分析肝动脉灌注化疗栓塞治疗原发性肝癌临床疗效及对患者血清指标与生命质量的影响。方法选取2020年1月至2022年10月于上饶市人民医院治疗的70例原发性肝癌患者作为研究对象,按照随机数字表法分为研究组与对照组,各35例。对照组采用经导管肝动脉栓塞治疗,研究组采用肝动脉灌注化疗栓塞治疗。比价两组临床疗效、血清学指标[血管内皮生长因子(vascular endothelial growth fac�tor,VEGF)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)]、生命质量及并发症发生情况。结果研究组治疗总有效率为91.43%,高于对照组的68.57%,差异有统计学意义(P<0.05)。治疗后,研究组血清VEGF、TNF-α及bFGF水平均低于对照组,差异有统计学意义(P<0.05)。治疗后,研究组生理功能、生理职能、情感职能、躯体疼痛、精神健康、社会功能、精力及总体健康评分均高于对照组,差异有统计学意义(P<0.05)。研究组并发症发生率为14.29%,低于对照组的37.14%,差异有统计学意义(P<0.05)。结论肝动脉灌注化疗栓塞治疗原发性肝癌,可促进患者血清指标水平恢复,改善其生命质量,增强临床疗效,降低并发症发生率,值得临床推广应用。

Objective To analyze the clinical efficacy of hepatic artery perfusion chemoembolization in the treatment of primary liver cancer and its effect on patients'serum indexes and quality of life.Methods 70 patients with primary liver cancer admitted to Shangrao People's Hospital from January 2020 to October 2022 were selected as the study subjects,they were divided into the study group and the control group according to the random number table method,with 35 cases in each group.The control group received transcatheter hepatic artery embolization,the study group received hepatic artery perfusion chemoembolization.The clinical efficacy,serological indicators(vascular endothelial growth factor[VEGF],tumor necrosis factor-α[TNF-α],basic fibroblast growth factor[bFGF]),quality of life and incidence of complications were compared between the two groups.Results The effective rate of treatment in the study group was 91.43%,which was higher than 68.57%in the control group,and the difference was statistically significant(P<0.05).After treatment,the serum VEGF,TNF-αand bFGF levels in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the physical functioning,physical functioning,emotional functioning,somatic pain,mental health,social functioning,energy and general health scores in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).The complication rate in the study group was 14.29%,which was lower than 37.14%in the control group,and the difference was statistically significant(P<0.05).Conclusion Hepatic artery perfusion chemoembolization for primary liver cancer,can promote the restoration of serum indicator levels in patients,improve the quality of life,enhance clinical efficacy,reduce the incidence of complications,which is worthy of clinical promotion and application.