气压治疗对结直肠癌患者术后血栓弹力图的影响

Effect of air pressure therapy on postoperative thromboelastogram in patients with colorectal cancer

目的探究气压治疗对结直肠癌患者术后血栓弹力图(thrombelastogram,TEG)的影响。方法选取2021年2月至2022年8月萍乡矿业集团有限责任公司总医院收治的60例行结直肠癌腹腔镜手术治疗的患者作为研究对象,采用随机数字表法分为两组,各30例。对照组采用术后常规干预,观察组采用术后气压治疗。比较两组凝血常规指标[凝血酶原时间(prothrombin time,PT)、活化部分凝血活酶时间(ac�tivated partial thromboplastin time,APTT)、纤维蛋白原(fibrinogen,Fg)及D-二聚体(D-dimer,D-D)水平]、TEG相关指标[凝血因子水平(reac�tion time,R)、纤维蛋白原时间(kinetics of clot development,K)、最大血块强度(maximum amplitude,MA)、凝固角(Angle)、凝血综合指数(co�agulation index,CI)]及血流动力学指标。结果术后第5天,两组PT、APTT均长于干预前,Fg及D-D水平均高于干预前,且观察组PT、APTT均长于对照组,Fg、D-D水平均高于对照组,差异有统计学意义(P<0.05)。术后第1、3、5天,观察组R均高于对照组,MA、Angle均大于对照组,CI均高于对照组,术后第1、5天,观察组K均长于对照组,差异有统计学意义(P<0.05);术后第3天,两组K比较差异无统计学意义。术后第3天,观察组血流量多于对照组,血流峰速度及血流平均速度均快于对照组,差异有统计学意义(P<0.05);术后第5天,两组血流量均多于术后第3天,血流峰速度及血流平均速度均快于术后第3天,且观察组血流量多于对照组,血流峰速度及血流平均速度均快于对照组,差异有统计学意义(P<0.05)。结论气压治疗结直肠癌效果显著,可显著改善患者术后凝血功能与血流动力学指标,值得临床推广应用。

Objective To investigate the effect of air pressure therapy on postoperative thromboelastogram(TEG)in patients with colorectal cancer.Methods 60 patients who underwent laparoscopic surgery for colorectal cancer at General Hospital of Pingxiang Mining Group Co.from February 2021 to August 2022 were selected as the study subjects,they were divided into the two groups using the random number table method,with 30 cases in each group.The control group was treated with routine postoperative intervention,and the observation group was treated with postoperative air pressure therapy.The conventional coagulation indicators(prothrombin time[PT],activated partial thromboplastin time[APTT],fibrinogen[Fg]and D-dimer[D-D]),TEG related indicators(reaction time[R],kinetics of clot development[K],maximum amplitude[MA],Angle and coagulation index[CI])and hemodynamic indicators were compared between the two groups.Results On the 5th day after operation,PT and APTT of the two groups were longer than those before intervention,Fg and D-D levels were higher than those before intervention,and PT and APTT in the observation group were longer than those in the control group,Fg and D-D levels were higher than those in the control group,the differences were statistically significant(P<0.05).On the 1st,3rd and 5th day after operation,R in the observation group was higher than that in the control group,MA and Angle were higher than those in the control group,and CI was higher than that in the control group;on the 1st and 5th day after operation,K in the observation group was longer than that in the control group,and the differences were statistically significant(P<0.05);on the 3rd day after operation,there was no significant difference in K between the two groups.On the 3rd day after operation,the blood flow in the observation group was more than that in the control group,and the peak velocity and average velocity of blood flow were faster than those in the control group,the differences were statistically significant(P<0.05).On the 5th day after operation,the blood flow of the two groups was more than that on the 3rd day after operation,the peak velocity and average velocity of blood flow were faster than those on the 3rd day after operation,and the blood flow in the observation group was more than that in the control group,the peak velocity and average velocity of blood flow were faster than those in the control group,the differences were statistically significant(P<0.05).Conclusion The effect of air pressure therapy in the treatment of colorectal cancer is significant,which can significantly improve the postoperative coagulation function and hemodynamic indexes of patients,which is worthy of clinical promotion and application.