巨噬细胞在心房颤动发生机制中作用的研究进展

Progress in role of macrophages in mechanism of atrial fibrillation

心房颤动(atrial fibrillation,AF)是一种临床常见的快速性心律失常,在过去的数十年中,AF的患病率随年龄的增长而增加。AF可以引起卒中、心力衰竭等严重并发症,是导致死亡的重要原因。在AF的发病机制中心房电重构、结构重构、氧化应激、炎性反应等起重要作用,近年观察到巨噬细胞在AF的发生发展中发挥关键作用。本文综述巨噬细胞在心房颤动发生机制的作用及其研究进展。

Atrial fibrillation(AF),a prevalent clinical tachyarrhythmia,has seen an increase in incidence with advancing age over recent decades.AF leads to severe complications,including stroke and heart failure,and is a sig-nificant cause of mortality.The pathogenesis of AF involves critical factors such as atrial electrical and structural remodeling,oxidative stress,and inflammatory responses.Recent studies highlight the pivotal role of macrophages in the initiation and progression of AF.This study focuses on the contributions of macrophages to the mechanisms of AF and summarizes cur-rent research findings.