1.5T磁共振成像可有效监测缺血性脑卒中大鼠模型不同时期的颅脑病变动态

1.5T magnetic resonance imaging can effectively moniter the dynamic changes of cerebral lesions in different stages of ischemic stroke in SD rats

目的评估临床医用1.5T磁共振成像技术在不同时间点(6 h、3 d、5 d、7 d、14 d)对急性缺血性脑卒中大鼠模型颅脑病变成像的可行性及其影像学特征变化。方法随机选择健康雄性SD大鼠10只(10~12周龄),通过线拴法建立永久性SD大鼠的大脑中动脉阻塞模型,使用医用1.5T MR成像仪在不同时间点(6 h、3 d、5 d、7 d、14 d)对大脑中动脉阻塞模型大鼠进行T1WI、T2WI、T2 FLAIR、DWI成像扫描,观察不同分期梗死大鼠脑磁共振图像形态及信号强度变化。结果1.5T MR成像仪所作DWI图像可以用于诊断大鼠超急性期脑梗死,并直观表现梗死程度和范围;模型鼠脑梗死病灶在不同分期呈现不同的影像学改变,随着时期进展,常规核磁序列呈现的大鼠梗死病灶信号强度及病灶形态有所改变。结论临床医用1.5T磁共振成像技术能够有效监测不同时间点缺血性脑卒中大鼠模型的颅脑病变动态变化,特别是DWI序列在超急性期梗死诊断中表现出色,为进一步的临床研究和治疗决策提供了有价值的影像学依据。

Objective To assess the feasibility and imaging characteristics of clinical 1.5T MRI in visualizing cerebral lesions at different time points(6 h,3 d,5 d,7 d,14 d)in an acute ischemic stroke rat model.Methods Ten healthy male Sprague-Dawley rats,aged 10-12 weeks,were randomly selected and subjected to permanent middle cerebral artery occlusion via the filament method to induce ischemic stroke.MRI scans,including T1WI,T2WI,T2 FLAIR,and DWI,were conducted using a 1.5T clinical MRI scanner at the specified time intervals(6 h,3 d,5 d,7 d,14 d),capturing morphological and signal intensity changes across infarction stages in the rats.Results The DWI sequence obtained from the 1.5T MRI scanner facilitated diagnosis of ultra-acute cerebral infarction in rats,effectively delineating infarction extent and scope.Infarct lesions in the model rats exhibited distinct imaging changes across stages,with signal intensity and morphology alterations becoming apparent in conventional MRI sequences as the infarction progressed.Conclusion The clinical 1.5T MRI technique proves effective in monitoring time-dependent dynamic changes in cerebral lesions in the ischemic stroke rat model.DWI,in particular,exhibits outstanding diagnostic capacity in ultra-acute infarction,thus providing valuable imaging support for advanced clinical research and therapeutic planning.