^(18)F-FDG PET/CT代谢参数联合血清肿瘤标志物有助于反映部分胃癌患者临床病理特征

^(18)F-FDG PET/CT metabolic parameters and serum tumor markers help reflect some clinicopathological features of gastric cancer

目的探讨^(18)F-FDG PET/CT代谢参数、血清肿瘤标志物与胃癌患者临床病理特征的相关性。方法回顾性分析2019年1月~2023年9月在我院核医学科行^(18)F-FDG PET/CT检查的41例经病理证实的胃癌患者^(18)F-FDG PET/CT影像资料和临床资料,测量胃癌原发灶的最大标准摄取值(SUV_(max))、平均标准摄取值(SUV_(mean))、峰值标准摄取值(SUV_(peak))、最大去脂肪标准摄取值(SUL)、糖酵解总量(TLG)、肿瘤代谢体积(MTV),并记录其血清肿瘤标志物表达水平。分别比较不同临床分期、肿瘤组织分化程度及Lauren分型组间代谢参数及肿瘤标志物的差异,并分析代谢参数、肿瘤标志物及临床病理特征之间的相关性。结果不同临床分期间SUV_(max)、SUV_(peak)、SUV_(mean)、SUL、TLG、MTV及癌胚抗原(CEA)、糖类抗原(CA)19-9、CA72-4阳性率检测值的比较,差异均有统计学意义(P<0.05)。不同肿瘤分化程度MTV的比较,差异有统计学意义(P<0.05),而SUV_(max)、SUV_(peak)、SUV_(mean)、SUL、TLG及CEA、CA19-9、CA72-4阳性率检测值的比较,差异无统计学意义(P>0.05)。不同Lauren分型间各指标的比较,差异均无统计学意义(P>0.05)。SUVmax、SUV_(peak)、SUV_(mean)、SUL、TLG、MTV与CEA、CA19-9、CA72-4联合预测临床分期的正确率可达92.7%。结论^(18)F-FDG PET/CT代谢参数联合血清肿瘤标志物有助于反映肿瘤的部分临床病理特征,对于临床制定个体化治疗方案具有重要意义。

Objective To investigate the correlation between^(18)F-FDG PET/CT metabolic parameters,serum tumor markers and clinicopathological characteristics of patients with gastric cancer.Methods The^(18)F-FDG PET/CT imaging data and clinical data of 41 patients with pathologically confirmed gastric cancer who underwent^(18)F-FDG PET/CT in the Department of Nuclear Medicine of our hospital from January 2019 to September 2023 were retrospectively analyzed.Standardized uptake value(SUV)max,SUV_(peak),SUV_(mean),maximum standard intake value for fat removal(SUL),tumor metabolic volume(MTV)and total glycolysis(TLG)of primary gastric cancer were measured,and the expression levels of serum tumor markers were recorded.The differences of metabolic parameters and tumor markers among different clinical stages,tumor tissue differentiation and Lauren classification groups were compared,and the correlation between metabolic parameters,tumor markers and clinicopathological characteristics was analyzed.Results There were significant differences in SUV_(max),SUV_(peak),SUV_(mean),SUL,TLG,MTV,and the positive detection values of carcinoembryonic antigen(CEA),carbohydrate antigen(CA)19-9 and CA72-4 in different clinical stages(P<0.05).There was a significant difference in MTV among different tumor differentiation(P<0.05),while there was no significant difference in SUV_(max),SUV_(peak),SUVmean,SUL,TLG and the positive detection values of CEA,CA19-9 and CA72-4(P>0.05).There was no significant difference in each index between different Lauren types(P>0.05).The accuracy of SUVmax,SUVpeak,SUVmean,SUL,TLG,MTV combined with CEA,CA19-9,CA72-4 in predicting clinical stage reached 92.7%.Conclusion^(18)F-FDG PET/CT metabolic parameters combined with serum tumor markers can help to reflect some of the clinicopathological characteristics of tumors,which is of great significance for the development of clinical individualized treatment plan.