PET/CT在类风湿性关节炎滑膜成像中的研究进展

Application of PET/CT in synovial imaging of rheumatoid arthritis

类风湿性关节炎(RA)是一种全身性炎症性疾病,通常表现为多发性关节炎,但可有多系统受累和并发症,导致发病率和死亡率增加。由于其临床表现多样,RA的诊断仍然具有挑战性。PET越来越多地用于RA的诊断、监测治疗反应、预测缓解和诊断亚临床并发症。在这篇文章中,总结针对RA关节滑膜内的不同细胞所产生的因子进行分类综述,并对最近的研究热点,如PET/MRI及RA中的免疫细胞进行分析比较。尽管PET已经发展成为一种有前途的评估和管理RA的工具,但在将PET纳入RA的标准临床管理之前,还需要更多的证据。

Rheumatoid arthritis(RA)is a systemic inflammatory disease that typically presents as polyarthritis but can involve multiple systems and lead to increased morbidity and mortality.Due to its diverse clinical manifestations,the diagnosis of RA remains challenging.PET is increasingly utilized for diagnosing RA,monitoring treatment response,predicting remission,and detecting subclinical complications.This paper summarizes the factors produced by different cells in the synovial membrane of RA joints and analyzes and compares recent research hotspots such as PET/MRI and immune cells in RA.Although PET has shown promise as a tool for assessing and managing RA,more evidence is needed before it can be included in standard clinical management.