代谢性谷氨酸受体5 PET显像在抑郁症诊断和治疗监测中的潜在价值

The potential value of metabolic glutamate receptor 5 PET imaging in the diagnosis and treatment monitoring of depression

抑郁症是一种常见的精神障碍,但其发病机制错综复杂,至今仍不完全清楚。研究表明代谢性谷氨酸受体5(mGluR5)在抑郁症的病理生理学中起关键作用。抑郁动物模型研究及体外放射自显影技术为mGluR5在抑郁症的变化提供了的见解,但由于其向临床转化的局限性限制了进一步了解抑郁症。随着PET及放射性配体的不断发展,核素非介入性受体显像使得在体研究抑郁症mGluR5的可用性成为可能。本综述总结了mGluR5 PET放射性配体的发展,提供了支持mGluR5参与抑郁症病理生理过程的临床和临床前PET在体研究结果,讨论了mGluR5 PET显像在抑郁症中的潜在价值。

Depression is a common mental disorder,but its pathogenesis is intricate and there is still only a partial understanding of its underlying pathophysiology.Studies have shown that metabolic glutamate receptor 5(mGluR5)plays a key role in the pathophysiology of depression.Depression animal model studies and in vitro radiotracer autoradiography have provided insights into the changes of mGluR5 in depression,but limitations in its translation to the clinic have restricted further understanding of depression.With the continued development of PET and radiotracers,nuclide noninvasive receptor imaging has made it possible to study the availability of mGluR5 for depression in vivo.This review summarised the development of the mGluR5 PET radioligand,provided the results of clinical and preclinical PET in vivo studies supporting the involvement of mGluR5 in the pathophysiological processes of depression,and discussed the potential value of mGluR5 PET imaging in depression.