慢性鼻窦炎小鼠建模研究进展

Research progress in the establishment of mouse models of chronic rhinosinusitis

慢性鼻部炎症如鼻炎、鼻窦炎是一类常见慢性疾病,长期影响人们的生活质量,其发病原因和致病机制仍尚不明确,动物模型的构建是探寻致病机制有效途径,其中小鼠慢性鼻部炎症模型的建立在近几年得到快速发展。本综述旨在总结国内外小鼠慢性鼻窦炎、过敏性鼻炎建模情况,特别是嗜酸性粒细胞性慢性鼻窦炎小鼠模型的进展,这对于开发防治慢性鼻部炎症的新药或进一步阐明其发病机制均有重要作用。

Chronic nasal inflammation,such as rhinitis and sinusitis,is a common chronic disease that affects people’s quality of life for a long period of time.Its pathogenesis and mechanism are still unclear.The establishment of animal models is an effective approach to explore the pathogenesis,among which the establishment of mouse models of chronic nasal inflammation has been rapidly developed in recent years.The aim of this review is to summarize the research status of chronic rhinosinusitis and allergic rhinitis modeling in mice at home and abroad,especially the progress in eosinophilic chronic rhinosinusitis mouse models,which plays an important role in the development of new drugs to prevent and control chronic nasal inflammation or further elucidation of its pathogenesis.