类器官肺损伤疾病模型构建及应用的研究进展

Research progress on the construction and application of disease models of lung injury with organoidbased approach

肺类器官是由成体干细胞或多能干细胞在3D培养条件下形成的具有一定空间结构的组织类似物,能够在一定程度上模拟人体组织的结构和功能。目前,肺类器官已开始应用于肺损伤疾病模型的构建,特别是在吸入性肺损伤和由感染性疾病导致的肺损伤中成为研究热点。本文对近年来类器官肺损伤疾病模型构建和应用的研究进展进行综述,以期为更多肺损伤模型的构建提供启发。

Lung organoids are tissue analogues with a certain spatial structure formed by adult stem cells or pluripotent stem cells under 3D culture conditions,which can simulate the structure and function of human tissues to a certain extent.At present,lung organoids have been applied in the construction of lung injury disease models,especially in inhalation lung injury and lung injury caused by infectious diseases.This paper reviews the construction and application of organoids in lung injury disease models in recent years,in order to provide inspiration for the construction of more lung injury models.