异体富血小板血浆在创面修复中的临床应用进展

Clinical advances in the application of allogeneic platelet- rich plasma in wound healing

复杂难愈性创面的愈合受多种因素调控,可严重影响患者身心健康,给社会带来经济负担。因此,寻找创新策略以加速复杂难愈创面的愈合显得尤为重要。自体富血小板血浆(PRP)对创面愈合的积极影响已得到广泛认可,但其临床应用仍存在诸多限制。相较之下,异体PRP作为一种前景广阔的替代方法,为临床治疗提供了新的方向。本文通过探讨异体PRP在促进创面修复中的机制,展示其在难愈创面中的临床应用实例,分析异体PRP的安全性、局限性及其未来的发展方向。

The healing of complex and hard-to-heal wounds is influenced by multiple factors,significantly impacting the patient′s physical and mental health as well as social economic burden.Therefore,seeking innovative strategies to accelerate the healing process of these wounds is particularly important.Autologous platelet-rich plasma(PRP)has been widely recognized for its positive effect on wound healing,yet its clinical application is still limited due to various constraints.In contrast,allogeneic PRP,as a promising alternative approach,offers a new direction for clinical treatment.This review explores the mechanism of allogeneic PRP in promoting wound repair,presents clinical application examples in hard-toheal wounds,analyzes the safety and limitations of allogeneic PRP,and envisions its future development prospects.