可视化分析结直肠癌领域中炎性反应相关研究的热点与趋势

Visual Analysis of Hotspots and Trends in Inflammation-Related Research in Colorectal Cancer

目的 分析归纳结直肠癌领域中炎性反应相关研究的热点及发展趋势。方法 从Web of Science核心合集中检索2000—2023年结直肠癌领域中炎性反应相关研究的文献,运用VOSviewer、CiteSpace、Bibliometrix R-package和Scimago Graphica进行文献计量与可视化分析。结果 该领域相关研究的年度发文量逐年增加,美国、中国、英国等国家对该领域贡献巨大,哈佛大学、美国国家癌症研究所、上海交通大学是该领域发文量前三的机构。International Journal of Mole Cular Sciences是出版该领域研究文献最多的期刊。Hébert JR是发表该领域文献最多的作者,现已形成了多个结构稳定的研究团队,团队间合作相对缺乏。炎性反应对结直肠癌发生、发展、治疗和预后的影响及其分子机制为该领域研究的主要内容。结论“具核梭杆菌”“免疫治疗”“药物递送”“肠道微生物群”“肿瘤微环境”“代谢物”“网络药理学”是该领域研究的热点与前沿。进一步探索炎性反应与结直肠癌之间的相关性及其相互影响的作用机制,优化结直肠癌的预防策略,并探索新的治疗靶点和治疗措施是该领域未来研究趋势。

Objective To analyze and summarize the research hotspots and trends in inflammation-related research in colorectal cancer(CRC).Methods Studies on CRC and inflammation from 2000 to 2023 were retrieved from the Web of Science core collection.VOSviewer,CiteSpace,the Bibliometrix R package,and Scimago Graphica were used for bibliometric and visual analysis.Results The annual publication volume in this field has increased year by year,with significant contributions from countries such as the United States,China,and the United Kingdom.Harvard University,the National Cancer Institute,and Shanghai Jiao Tong University are the top three institutions in terms of publication volume in this field.International Journal of Molecular Sciences is the journal that has published the most research literature in this field.Hébert JR is the author who published the most papers.Several longstanding research teams have been formed,but relatively lacking cooperation between teams.The effect of inflammation on the occurrence,development,treatment,and prognosis of colorectal cancer and its molecular mechanisms are the main focus of research in this field.Conclusion“Fusobacterium nucleatum”“immunotherapy”“drug delivery”“gut microbiota”“tumor microenvironment”“metabolites”and“network pharmacology”are the hotspots and frontiers of research in this field.Further exploration of the correlation between inflammation and CRC and the mechanisms of their mutual influence,optimization of prevention strategies for CRC,and exploration of new therapeutic targets and treatments are future research trends.