摘要
点击化学是最重要的生物正交化学反应,它像“乐高”一样将分子连接起来。点击化学正深刻影响着肿瘤研究,例如修饰肿瘤细胞、设计肿瘤药物、传输肿瘤药物、药物临床前评估和操控免疫细胞。点击化学也将被用于分子发现和靶向治疗,为肿瘤研究提供新方法。
As one of the typical bioorthogonal chemistry reactions,click chemistry joins molecules similar to“Lego”.Bioorthogonal click chemistry is used to modify cancer cells,design antitumor drugs,delivery drugs,manipulate immune cells,and help preclinical evaluation.Click chemistry provides a promising approach for discovering molecules and targeting cancer in cancer research.
作者
张百红
岳红云
ZHANG Baihong;YUE Hongyun(Department of Oncology,940th Hospital of Joint Logistics Support Force of People's Liberation Army,Lanzhou 730050,China;Department of Ophthalmology,940th Hospital of Joint Logistics Support Force of People's Liberation Army,Lanzhou 730050,China)
出处
《肿瘤防治研究》
CAS
2024年第11期951-955,共5页
Cancer Research on Prevention and Treatment
基金
甘肃省自然科学基金(22JR5RA007)
联勤保障部队第九四〇医院课题(2021yxky052)。
关键词
肿瘤
点击化学
生物正交化学
肿瘤研究
Cancer
Click chemistry
Bioorthogonal chemistry
Cancer research