肠道菌群与产科疾病的相关性研究进展

Correlation between gut microbiota and obstetric diseases:research progress

近年来,越来越多的研究表明,肠道菌群对肠道环境产生各种影响,甚至可影响远端器官和通路。肠道菌群通过与雌激素、雄激素、胰岛素及其他激素相互作用,影响女性一生的生殖内分泌系统。妊娠期女性的肠道菌群在妊娠期间会发生显著变化,肠道菌群组成失衡可导致多种合并症和并发症的发生,如早产、妊娠期高血压疾病、妊娠期糖尿病、妊娠期甲状腺功能减退及肥胖等,但其机制研究有限。本文就目前肠道菌群与产科疾病之间的相关性研究进行综述,探讨肠道菌群介导产科疾病的潜在原因和潜在机制,以期为未来的相关研究提供新的思路。

In recent years,an increasing number of studies have shown that gut microbiota exerts various effects on intestinal milieu,which influences distant organs and pathways.Gut microbiota affects the reproductive endocrine system throughout a woman's lifetime by interacting with estrogen,androgens,insulin and other hormones.The gut microbiota of pregnant women changes significantly during pregnancy,and the imbalance of gut microbiota composition can lead to several comorbidities and complications,such as preterm birth,gestational hypertensive disorders,gestational diabetes,gestational hypothyroidism,and obesity etc.However,there is limited research on the mechanisms.This paper reviewed the correlation between gut microbiota and obstetric diseases,discussed the potential causes and underlying mechanisms of microbiota-mediated disease,in order to provide new ideas for future research.