髓三脏汤治疗肝肾阴虚型绝经后骨质疏松症的临床疗效评价

Clinical Efficacy of Suisanzang Decoction in Treating Post-Menopausal Osteoporosis with Liver and Kidney Yin Deficiency Type

目的:评价髓三脏汤对肝肾阴虚型绝经后骨质疏松患者的临床疗效。方法:将72例符合纳入标准的绝经后骨质疏松患者随机分为对照组和观察组,对照组予碳酸钙D3片、骨化三醇丸口服,观察组在对照组基础上加用髓三脏汤口服。两组均治疗3个月,比较两组患者干预前后骨密度、骨代谢指标及中医症候评分、疼痛评分。结果:对照组有效率为83.33%,观察组有效率为97.22%,观察组治疗效果明显优于对照组,差异有统计学意义(P<0.05)。观察组改善疼痛评分和中医症候评分高于对照组,差异有统计学意义(P<0.01)。两组治疗后观察组患者骨钙素总体上升水平高于对照组,差异有统计学意义(P<0.05)。结论:髓三脏汤治疗绝经后骨质疏松表现出较好的临床疗效,可能存在调控骨钙素、刺激骨形成的作用。

Objective:To evaluate the clinical efficacy of Suisanzang decoction in treating postmenopausal osteoporosis(PMOP)patients with liver and kidney Yin deficiency type.Methods:72 post-menopausal osteoporosis patients who met the inclusion criteria were randomly divided into control group and observation group.The control group was given calcium carbonate D3 tablets and calcitriol capsules orally,while the observation group was given Suisanzang decoction orally in addition to the control group.Both groups were treated for 3 months.The bone density,bone metabolism indicators,traditional Chinese medicine syndrome scores,and pain scores between two groups before and after intervention were compared.Results:The effective rate of the control group was 83.33%,while the effective rate of the observation group was 97.22%.The treatment efficacy of the observation group was significantly better than that of the control group(P<0.05).The effect of improving pain scores and traditional Chinese medicine syndrome scores in the observation group was greater than that in the control group,with significant differences(P<0.01).After treatment,the overall increase in BGP in the observation group was greater than that in the control group(P<0.05).Conclusion:Suisanzang decoction show good clinical efficacy on the treatment of PMOP,and may have the effects of regulating BGP and stimulating bone formation.