辅助性T细胞17在股骨头坏死发生发展中的作用

The Role of Helper T Cells 17 in the Development of Osteonecrosis of the Femoral Head

股骨头坏死是指股骨头血供中断引起骨组织坏死的一种疾病,其确切的发病机制至今尚未完全明确。辅助性T细胞17(Helper T Cell 17,Th17)作为骨免疫系统的关键细胞类型T淋巴细胞(T-lymphocyte)的亚群,在股骨头坏死的发生发展中起着至关重要的作用。概述Th17细胞在股骨头坏死炎症反应、股骨头细胞凋亡、股骨头血管生成中的作用以及Th17细胞与其他免疫细胞的相互作用,探讨其在股骨头坏死中的作用机制。Th17细胞的调控作用可能成为股骨头坏死治疗的一种新的方向和选择,其具体机制需要进一步的实验室研究和临床验证。

Osteonecrosis of the femeral head(ONFH)is a disease in which the blood supply to the femoral head is interrupted and the exact pathogenesis of bone tissue is not fully understood.Helper T cell 17(Th17),as a subset of T-lymphocytes,a key cell type of the bone immune system,plays a crucial role in the occurrence and development of ONFH.This article summarizes the role of Th17 cells in ONFH inflammatory response,apoptosis of femoral head cells,angiogenesis of femoral head,and the interaction of Th17 cells with other immune cells,explores its mechanism of action in ONFH as well.The regulatory role of Th17 cells may become a new direction and option for ONFH treatment,and its specific mechanism needs further laboratory and clinical validation.