17β-雌二醇对创伤后应激障碍恐惧记忆消退作用的研究进展

Research progress on the effects of 17β-estradiol on fear memory extinction in post-traumatic stress disorder

恐惧记忆消退受损是创伤后应激障碍(post-traumatic stress disorder,PTSD)的主要病理机制。恐惧记忆消退是指在无条件刺激(恐惧刺激)不呈现的情况下反复呈现条件刺激,进而消除个体已有的恐惧反应。17β-雌二醇作为一种神经保护因素,在调节介导海马的学习记忆功能方面起着关键作用,通过影响腹内侧前额叶、杏仁核和海马脑区等与消退学习有关的神经回路活动,调节恐惧消退学习效果。本文拟系统地探讨17β-雌二醇的来源、特点及其在PTSD恐惧记忆消退中发挥的重要效应,以期为研究PTSD的发病机制并寻找新的预防或干预靶点提供科学依据。

Impairment in Fear Memory Fading is a major pathological mechanism of Post-traumatic Stress Disorder(PTSD).Fear memory extinction refers to repeatedly presenting of a conditioned stimulus without the unconditioned(fear)stimulus,therefore eliminating the individual′s previously conditioned fear response.As a neuroprotective factor,17β-estradiol is critical in regulating learning memory functions in hippocampal-mediated learning and memory functions.It influences the activity of neural circuits related to extinction learning,including the ventral medial prefrontal,amygdala,and hippocampus,thereby modulating the effectiveness of fear extinction learning.This paper aims to systematically explore the source characteristics,and key effects of 17β-estradiol in the extinction of fear memory in PTSD,providing a scientific basis for studying pathogenesis of PTSD and identifying new targets for prevention or intervention.