盐酸氨溴索联合乙酰半胱氨酸在儿童重症肺炎治疗中的应用效果分析

Analysis of the application effect of ambroxol hydrochloride combining with acetylcysteine in the treatment of severe pneumonia in children

目的 分析盐酸氨溴索联合乙酰半胱氨酸在儿童重症肺炎治疗中的应用效果。方法 选取2023年1月~12月收治的75例重症肺炎患儿,按照随机数字法分为对照组(n=37)和观察组(n=38),所有患儿均进行退热、止咳、抗炎、维持水电解质平衡等常规基础治疗。对照组进行盐酸氨溴索治疗,观察组进行盐酸氨溴索联合乙酰半胱氨酸治疗。对两组临床疗效、肺功能、免疫功能、症状消失时间、炎症因子和不良反应进行评估。结果 治疗后,观察组的总有效率为94.74%,对照组的总有效率为75.68%,观察组高于对照组(P<0.05)。治疗后,观察组的第1秒用力呼气容积占用力肺活量的比值(FEV_(1)/FVC)、第1秒用力呼气容积占预计值百分比(FEV_(1)%)、最大呼气流速(PEF)指标均高于对照组(P <0.05)。治疗后,观察组的免疫球蛋白M(IgM)、免疫球蛋白A(IgA)、免疫球蛋白G(IgG)及补体C3指标均高于对照组(P <0.05)。治疗后,观察组的高热、气促、肺部湿啰音、咳嗽咯痰、肺部X线阴影等症状消失时间均低于对照组(P <0.05)。治疗后,观察组的超敏-C反应蛋白(hs-CRP)、γ-干扰素(IFN-γ)、肿瘤坏死因子-α(TNF-α)水平均低于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P> 0.05)。结论 儿童重症肺炎采用盐酸氨溴索联合乙酰半胱氨酸治疗效果显著,可以加快患儿的症状消失时间,提高患儿的肺功能和免疫功能,降低患儿的炎症因子水平,且具有良好的安全性。

Objective To analyze the application effect of ambroxol hydrochloride and acetylcysteine in the treatment of severe pneumonia in children.Methods A total of 75 children with severe pneumonia admitted from January to December 2023 were divided into the control group(n=37)and the observation group(n=38)according to the random number method,all the children received conventional basic treatment,such as fever reduction,cough suppression,anti-inflammatory treatment,and maintaining water and electrolyte balance.The control group was treated with ambroxol hydrochloride,and the observation group was treated with ambroxol hydrochloride and acetylcysteine.The clinical efficacy,lung function,immune function,symptom disappearance time,inflammatory factors and adverse reactions of the two groups were evaluated.Results After treatment,the total effective rate of the observation group was 94.74%,and that of the control group was 75.68%,the total effective rate of the observation group was higher than that of the control group(P<0.05).After treatment,the PEF,FEV1%and FEV1/FVC indexes in the observation group were higher than those in the control group(P<0.05).After treatment,the indexes of IgM,IgA,IgG and complement C3 in the observation group were higher than those in the control group(P<0.05).After treatment,the symptom disappearance times of hyperthermia,shortness of breath,crackles in the lungs,cough and sputum and X-ray shadows in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of IFN-γ,TNF-αand hs-CRP in the observation group were lower than those in the control group(P<0.05).After treatment,there was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Ambroxol hydrochloride combining with acetylcysteine are effective in the treatment of severe pneumonia in children,which can speed up the disappearance time of symptoms,improve the lung function and immune function of children,reduce inflammatory factors in children,and have a good safety profile.