高危型人乳头瘤病毒感染影响因素及其与阴道微生态系统的关联分析

Influencing factors of high-risk HPV infection and its association with vaginal micro ecosystem

目的分析与高危型人乳头瘤病毒(HR-HPV)感染相关的影响因素,并判断其与阴道微生态系统的关联性。方法将我院2023年1月至2024年1月110例进行筛查的女性作为研究对象,根据HR-HPV感染情况分为感染组(33例)与未感染组(77例),分析HR-HPV感染的影响因素分析,对2组研究对象阴道微生态进行比较,分析HR-HPV感染与阴道微生态的关联。结果感染组患者初次性生活年龄≤20岁、性伴侣人数≥2人、非避孕套避孕方式、乳酸杆菌比例异常、细菌性阴道病阳性占比均高于非感染组,差异有统计学意义(P<0.05);以单因素分析中差异有统计学意义的资料为自变量,HR-HPV感染为因变量,经多因素logistic回归分析显示,初次性生活年龄≤20岁、性伴侣人数≥2岁、非避孕套避孕方式、乳酸杆菌比例异常、细菌性阴道病阳性为HR-HPV感染的独立危险因素[OR值(95%CI)分别为:2.273(1.347,3.836)、2.370(1.537,3.655)、2.289(1.447,3.621)、2.252(1.427,3.556)、2.309(1.404,3.799),P均<0.05]。结论初次性生活年龄≤20岁、性伴侣人数≥2人、非避孕套避孕方式为HR-HPV感染的独立危险因素,乳酸杆菌比例异常、细菌性阴道病可能促进HR-HPV的感染。

Objective To analyze the influencing factors associated with high-risk HPV(HR-HPV)infection and determine its association with vaginal micro ecosystem.Methods One hundred and ten women who were screened in our hospital from January 2023 to January 2024 were selected as the research subjects.According to the HR-HPV infection,they were divided into infection group(33 cases)and non-infection group(77 cases).The influencing factors of HR-HPV infection were analyzed.The vaginal microecology of the two groups was compared,and the relationship between HR-HPV infection and vaginal microecology was analyzed.Results The age of first sexual life≤20,the number of sexual partners≥2,non-condom contraceptive methods,the abnormal proportion of Lactobacillus,and the positive proportion of bacterial vaginosis in the infection group were higher than those in the non-infection group,and the differences were statistically significant(P<0.05);Taking the data with statistically significant difference in univariate analysis as the independent variable and HR-HPV infection as the dependent variable,multivariate logistic regression analysis showed that age at first sexual life≤20,number of sexual partners≥2,non-condom contraceptive methods,abnormal proportion of Lactobacillus,and positive bacterial vaginosis were independent risk factors for HR-HPV infection(OR=2.273,2.370,2.289,2.252,2.309,P<0.05).Conclusion Age at first sexual life≤20,number of sexual partners≥2,and non-condom contraceptive methods are independent risk factors for HR-HPV infection.Abnormal proportion of Lactobacillus and bacterial vaginosis may promote HR-HPV infection.