银杏达莫注射液联合阿替普酶静脉溶栓治疗急性脑梗死患者的效果

Effects of Ginkgo leaf extract and Dipyridamole injection combined with Alteplase intravenous thrombolysis in treatment of patients with acute cerebral infarction

目的:观察银杏达莫注射液联合阿替普酶静脉溶栓治疗急性脑梗死患者的效果。方法:选取2022年2月至2024年3月该院收治的70例急性脑梗死患者进行前瞻性研究,按照随机数字表法分为观察组与对照组各35例。对照组采用阿替普酶静脉溶栓治疗,观察组在对照组基础上联合银杏达莫注射液治疗,比较两组美国国立卫生研究院卒中量表(NIHSS)评分、血液流变学指标(全血低切黏度、全血中切黏度、全血高切黏度)水平、血清炎性因子[C反应蛋白(CRP)、白细胞介素-6(IL-6)与肿瘤坏死因子-α(TNF-α)]水平、神经损伤标志物[脑源性神经营养因子(BDNF)、神经生长因子(NGF)、神经元特异性烯醇化酶(NSE)]水平和不良反应发生率。结果:治疗后,两组NIHSS评分,全血低切黏度、全血中切黏度、全血高切黏度等血液流变学指标水平,以及血清IL-6、TNF-α、CRP等血清炎性因子水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组血清BDNF、NGF水平均高于治疗前,且观察组高于对照组,两组NSE水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:银杏达莫注射液联合阿替普酶静脉溶栓治疗急性脑梗死患者可改善神经损伤标志物水平,降低NIHSS评分、血液流变学指标水平和炎性因子水平,效果优于单纯阿替普酶静脉溶栓治疗。

Objective:To observe effects of Ginkgo leaf extract and Dipyridamole injection combined with Alteplase intravenous thrombolysis in treatment of patients with acute cerebral infarction.Methods:A prospective study was conducted on 70 patients with acute cerebral infarction admitted to the hospital from February 2022 to March 2024.According to the random number table method,they were divided into observation group and control group,35 cases in each group.The control group was treated with Alteplase intravenous thrombolysis,while the observation group was treated with Ginkgo leaf extract and Dipyridamole injection on the basis of that of the control group.The National Institutes of Health stroke scale(NIHSS)score,the levels of hemorheological indexes(whole blood low shear viscosity,whole blood middle shear viscosity,whole blood high shear viscosity),serum inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)]and nerve injury markers[brain-derived neurotrophic factor(BDNF),nerve growth factor(NGF),neuron-specific enolase(NSE)],and the incidence of adverse reactions were compared between the two groups.Results:After the treatment,the NIHSS score and the levels of hemorheology indexes such as whole blood low shear viscosity,whole blood middle shear viscosity,whole blood high shear viscosity and serum inflammatory factors such as serum IL-6,TNF-αand CRP in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of serum BDNF and NGF in the two groups were higher than those before the treatment,and those in the observation group were higher than those in the control group;the NSE levels of the two groups were lower than those before the treatment,and that in the observation group was lower than that in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Ginkgo leaf extract and Dipyridamole injection combined with Alteplase intravenous thrombolysis in the treatment of the patients with acute cerebral infarction can improve the levels of nerve injury markers,and reduce the NIHSS scores,the hemorheology index levels and the inflammatory factor levels.Moreover,it is superior to simple Alteplase intravenous thrombolysis treatment.