低分子量肝素钙联合胰岛素治疗高脂血症急性胰腺炎患者的效果

Effects of low molecular weight Heparin calcium combined with Insulin in treatment of patients with hyperlipidemic acute pancreatitis

目的:观察低分子量肝素钙联合胰岛素治疗高脂血症急性胰腺炎患者的效果。方法:选取2020年4月至2024年4月该院收治的75例高脂血症急性胰腺炎患者进行前瞻性研究,按照随机数字表法将其分为对照组(n=37)和研究组(n=38)。对照组予以血浆置换治疗,研究组予以低分子量肝素钙联合胰岛素治疗,比较两组临床疗效,临床症状(血淀粉酶恢复时间、尿淀粉酶恢复时间、腹痛消失时间)改善时间,治疗前后炎性因子[白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)、降钙素原(PCT)]、血脂指标[总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)]水平。结果:研究组治疗总有效率为100.00%(38/38),高于对照组的81.78%(31/37),差异有统计学意义(P<0.05);研究组血淀粉酶恢复时间、尿淀粉酶恢复时间、腹痛消失时间均短于对照组,差异有统计学意义(P<0.05);治疗后,两组IL-6、hs-CRP及PCT水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后,两组TC、TG、LDL-C水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。结论:低分子量肝素钙联合胰岛素治疗高脂血症急性胰腺炎患者可提高治疗总有效率,缩短临床症状改善时间,以及降低炎性因子和血脂指标水平,效果优于血浆置换治疗。

Objective:To observe effects of low molecular weight Heparin calcium combined with Insulin in treatment of patients with hyperlipidemic acute pancreatitis.Methods:A prospective study was conducted on 75 patients with hyperlipidemic acute pancreatitis admitted to the hospital from April 2020 to April 2024.According to the random number table method,they were divided into control group(n=37)and study group(n=38).The control group was treated with plasma exchange,while the study group was treated with low molecular weight Heparin calcium combined with Insulin.The clinical efficacy,the improvement time of clinical symptoms(recovery time of blood amylase,recovery time of urine amylase,disappearance time of abdominal pain),and the levels of inflammatory factors[interleukin-6(IL-6),hypersensitive C-reactive protein(hs-CRP),procalcitonin(PCT)]and blood lipid[total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)]before and after the treatment were compared between the two groups.Results:The total effective rate of treatment in the study group was 100.00%(38/38),which was higher than 83.78%(31/37)in the control group,and the difference was statistically significant(P<0.05).The recovery time of blood amylase,the recovery time of urine amylase and the disappearance time of abdominal pain in the study group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IL-6,hs-CRP and PCT in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).Further,after the treatment,the levels of TC,TG and LDL-C in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusions:Low molecular weight Heparin calcium combined with Insulin in the treatment of the patients with hyperlipidemic acute pancreatitis can improve the total effective rate of treatment,shorten the improvement time of clinical symptoms,and reduce the levels of inflammatory factors and blood lipid indexes.Moreover,it is superior to plasma exchange.