胸腺五肽联合高效抗逆转录病毒治疗在艾滋病患者中的应用效果

Application effects of Thymopentin combined with highly active antiretroviral therapy in AIDS patients

目的:观察胸腺五肽联合高效抗逆转录病毒治疗(HAART)在艾滋病(AIDS)患者中的应用效果。方法:回顾性分析2020年7月至2023年7月该院收治的72例AIDS患者的临床资料,根据治疗方法不同将其分为对照组和观察组各36例。对照组给予HAART(替诺福韦^(+)拉米夫定^(+)依非韦伦),观察组在对照组基础上联合胸腺五肽治疗。比较两组治疗前后人类免疫缺陷病毒(HIV)病毒载量,细胞免疫功能指标[T淋巴细胞(CD4^(+)、CD8^(+))、Treg细胞、Th17]水平、炎性因子[γ干扰素(IFN-γ)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)]水平及不良反应发生率。结果:治疗后,两组HIV病毒载量均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组CD4^(+)、Th17水平均高于治疗前,且观察组高于对照组,两组CD8^(+)、Treg细胞水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组IFN-γ水平均高于治疗前,且观察组高于对照组,两组CRP、TNF-α水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:胸腺五肽联合HAART应用于AIDS患者,可降低病毒载量,提高机体细胞免疫功能,减轻机体炎症反应,效果优于单纯HAART。

Objective:To observe application effects of Thymopentin combined with highly active antiretroviral therapy(HAART)in AIDS patients.Methods:The clinical data of 72 AIDS patients admitted to the hospital from July 2020 to July 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,36 cases in each group.The control group was treated with HAART(Tenofovir^(+)Lamivudine^(+)Efavirenz),while the observation group was treated with Thymopentin on the basis of that of the control group.The human immunodeficiency virus(HIV)viral load,the cellular immune function indexes[T lymphocytes(CD4^(+),CD8^(+)),Treg cells,Th17]levels,the inflammatory factors[interferon-γ(IFN-γ),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:After the treatment,the HIV viral load of the two groups were lower than those before the treatment,that in the observation group was lower than that in the control group,and the differences were^(+)statistically significant(P<0.05).After the treatment,the levels of CD4 and Th17 in the two groups were higher than those before the treatment,and^(+)those in the observation group were higher than those in the control group;the levels of CD8 and Treg cells in the two groups were lower than those before the treatment,and those in the observation group were lower than those int he control group;and the difference was statistically significant(P<0.05).After the treatment,the levels of IFN-γin the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;the levels of CRP and TNF-αin the two groups were lower than those before the treatment,and the observation group was lower than the control group;the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Thymopentin combined with HAART in the AIDS patients can reduce the viral load,improve the cellular immune function and reduce the inflammatory response.Moreover,it is superior to simple HAART.