脑心通胶囊联合多奈哌齐治疗多发梗死性痴呆患者的效果

Effects of Naoxintong capsules combined with Donepezil in treatment of multi-infarct dementia

目的:观察脑心通胶囊联合多奈哌齐治疗多发梗死性痴呆患者的效果。方法:选取2023年4月至2024年3月该院收治的120例多发梗死性痴呆患者进行前瞻性研究,按随机数字表法将其分为研究组61例与对照组59例。对照组采用多奈哌齐治疗,研究组在对照组基础上联合脑心通胶囊治疗,比较两组临床疗效,治疗前后认知功能[蒙特利尔认知评估量表(MoCA)]评分、脑血液流变学指标[血浆黏度、全血低切黏度、血小板反应蛋白-1(THBS-1)、纤维蛋白原(FIB)]水平、中医证候积分,以及不良反应发生率。结果:研究组治疗总有效率为96.72%(59/61),高于对照组的84.75%(50/59),差异有统计学意义(P<0.05);治疗后,两组视空间执行能力、定向力、注意和延迟记忆、抽象思维和命名、语言流畅等MoCA评分均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组血浆黏度、全血低切黏度和THBS-1、FIB水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组双目呆滞、头晕昏沉、嗜睡涎多等中医证候积分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:脑心通胶囊联合多奈哌齐治疗多发梗死性痴呆患者可提高治疗总有效率和认知功能评分,改善脑血液流变学指标水平,降低中医证候积分的效果优于单纯多奈哌齐治疗。

Objective:To observe effects of Naoxintong capsules combined with Donepezil in treatment of multiple infarction dementia.Methods:A prospective study was conducted on 120 patients with multi-infarct dementia admitted to this hospital from April 2023 to March 2024.According to the random number table method,they were divided into study group(61 cases)and control group(59 cases).The control group was treated with Donepezil,while the study group was treated with Naoxintong capsules on the basis of that of the control group.The clinical efficacy,the cognitive function[Montreal cognitive assessment(MoCA)]score,the cerebral hemorheology indexes[plasma viscosity,whole blood low shear viscosity,thrombospondin-1(THBS-1),fibrinogen(FIB)]levels,and the TCM syndrome score before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 96.72%(59/61),which was higher than 84.75%(50/59)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the MoCA scores of visual space execution ability,orientation,attention and delayed memory,abstract thinking and naming,languagefluency in the two groups were higher than those before the treatment,those in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of plasma viscosity,whole blood low shear viscosity,THBS-1 and FIB in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The scores of TCM syndromes such as binocular stagnation,dizziness and drowsiness in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Naoxintong capsules combined with Donepezil in the treatment of the patients with multi-infarct dementia can improve the total effective rate and the cognitive function scores,improve the levels of cerebral hemorheology indexes,and reduce the scores of TCM syndrome.Moreover,it is superior to simple Donepezil treatment.