知柏地黄丸联合米诺环素软膏治疗慢性牙周炎患者的效果

Effects of Zhibai Dihuang pills combined with Minocycline ointment in treatment of patients with chronic periodontitis

目的:观察知柏地黄丸联合米诺环素软膏治疗慢性牙周炎患者的效果。方法:回顾性分析2020年5月至2023年3月该院收治的116例慢性牙周炎患者的临床资料,按照治疗方法不同将其分为对照组和研究组各58例。对照组采用米诺环素软膏治疗,研究组在对照组基础上联合知柏地黄丸治疗,比较两组临床疗效,治疗前后炎性指标[C反应蛋白(CRP)、降钙素原(PCT)、白细胞计数(WBC)]、龈沟液指标[核因子κB受体活化因子配体(RANKL)、巨噬细胞炎症蛋白-1α(MIP-1α)]、牙周指标[菌斑指数(PLI)、牙齿松动度(TM)、牙龈指数(GI)]水平和生命质量[简化牙本质敏感影响程度量表(DHEQ-15)]评分。结果:研究组治疗总有效率为89.66%(52/58),高于对照组的75.86%(44/58),差异有统计学意义(P<0.05);治疗后,研究组PCT、CRP和WBC水平均低于对照组,差异有统计学意义(P<0.05);治疗后,研究组龈沟液RANKL、MIP-1α水平均低于对照组,差异有统计学意义(P<0.05);治疗后,研究组TM、GI和PLI评分均低于对照组,差异有统计学意义(P<0.05);治疗后,研究组功能限制、饮食习惯变化、情感变化等DHEQ-15评分均低于对照组,差异有统计学意义(P<0.05)。结论:知柏地黄丸联合米诺环素软膏治疗慢性牙周炎患者可提高治疗总有效率,降低炎性指标、龈沟液指标、牙周指标水平和生命质量评分,效果优于单纯米诺环素软膏治疗。

Objective:To observe effect of Zhibai Dihuang pills combined with Minocycline ointment in treatment of patients with chronic periodontitis.Methods:The clinical data of 116 patients with chronic periodontitis admitted to the hospital from May 2020 to March 2023 were retrospectively analyzed.According to the different treatment methods,they were divided into control group and study group,58 cases in each group.The control group was treated with Minocycline ointment,while the study group was treated with Zhibai Dihuang pills on the basis of that of the control group.The clinical efficacy,the levels of inflammatory indexes[C-reactive protein(CRP),procalcitonin(PCT),white blood cell count(WBC)],gingival crevicularfluid indexes[receptor activator of nuclear factor-κB ligand(RANKL),macrophage inflammatory protein-1α(MIP-1α)]and periodontal indexes[plaque index(PLI),tooth mobility(TM),gingival index(GI)],and the quality of life[dentine hypersensitivity experience questionnaire(DHEQ-15)]scores were compared between the two groups before and after the treatment.Results:The total effective rate of treatment in the study group was 89.66%(52/58),which was higher than 75.86%(44/58)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of PCT,CRP and WBC in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of RANKL and MIP-1αin gingival crevicularfluid in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the scores of TM,GI and PLI in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the DHEQ-15 scores of functional limitation,eating habits and emotional changes in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusions:Zhibai Dihuang pills combined with Minocycline ointment in the treatment of the patients with chronic periodontitis can improve the total effective rate of treatment and reduce the levels of inflammatory indexes,gingival crevicularfluid indexes and periodontal indexes and the quality of life scores.Moreover,it is superior to simple Minocycline ointment treatment.