保妇康栓联合人干扰素α2b治疗慢性宫颈炎伴HPV感染患者的效果

Effects of Baofukang suppository combined with human interferonα2b in treatment of patients with chronic cervicitis and HPV infection

目的:观察保妇康栓联合人干扰素α2b治疗慢性宫颈炎伴人乳头状瘤病毒(HPV)感染患者的效果。方法:选取2022年9月至2023年5月该院收治的100例慢性宫颈炎伴HPV感染患者进行前瞻性研究,按照随机数字表法将其分为对照组和研究组各50例。对照组给予人干扰素α2b治疗,研究组在对照组基础上联合保妇康栓治疗。比较两组临床症状(腰骶部疼痛、外阴瘙痒、阴道分泌物异常)改善时间,HPV转阴率,治疗前后炎性因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)]水平,不良反应发生率,以及复发率。结果:研究组腰骶部疼痛、外阴瘙痒及阴道分泌物异常等临床症状改善时间均短于对照组,差异有统计学意义(P<0.05);治疗1、2、3个疗程后,研究组HPV转阴率均高于对照组,差异有统计学意义(P<0.05);治疗后,两组IL-6、TNF-α及hs-CRP水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05);治疗后1、3个月,两组复发率比较,差异均无统计学意义(P>0.05);治疗后6个月,研究组复发率低于对照组,差异有统计意义(P<0.05)。结论:保妇康栓联合人干扰素α2b治疗慢性宫颈炎伴HPV感染患者可提高HPV转阴率,缩短临床症状改善时间,以及降低炎性因子水平和复发率的效果优于单纯人干扰素α2b治疗效果。

Objective:To observe effects of Baofukang suppository combined with human interferonα2b in treatment of chronic cervicitis combined with human papillomavirus(HPV)infection.Methods:A prospective study was conducted on 100 patients with chronic cervicitis and HPV infection admitted to this hospital from September 2022 to May 2023.According to the random number table method,they were divided into control group and study group,50 cases in each group.The control group was treated with human interferonα2b,while the study group was treated with Baofukang suppository on the basis of that of the control group.The improvement time of clinical symptoms(lumbosacral pain,vulva pruritus,abnormal vaginal secretion),the HPV negative conversion rate,the levels of inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(hs-CRP)]before and after the treatment,the incidence of adverse reactions,and the recurrence rate were compared between the two groups.Results:The improvement time of clinical symptoms such as lumbosacral pain,vulva pruritus and abnormal vaginal secretions in the study group was shorter than that in the control group,and the difference was statistically significant(P<0.05).After 1,2 and 3 courses of treatment,the negative conversion rate of HPV in the study group was higher than that in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of IL-6,TNF-αand hs-CRP in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).1 and 3 months after the treatment,there were no significant differences in the recurrence rate between the two groups(P>0.05).After 6 months of treatment,the recurrence rate of the study group was lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusions:Baofukang suppository combined with human interferonα2b in the treatment of the patients with chronic cervicitis and HPV infection can improve the negative conversion rate of HPV,shorten the improvement time of clinical symptom indicators,and reduce the levels of inflammatory factors and the recurrence rate.Moreover,it is superior to simple human interferonα2b treatment.