普萘洛尔治疗婴幼儿血管瘤的疗效与安全性

Efficacy and safety of propranolol in the treatment of infantile hemangioma

目的研究婴幼儿血管瘤(IH)治疗中普萘洛尔应用的疗效与安全性。方法将厦门市儿童医院2021年1月至2023年12月50例IH患儿按治疗方法分为对照组和研究组,每组25例,对照组接受聚桂醇注射液治疗,研究组接受盐酸普萘洛尔片治疗,比较2组疗效。结果研究组总有效率(92%)高于对照组(68%)(P<0.05);治疗后4周、治疗后8周,2组血管生成因子水平均降低,研究组血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)水平低于对照组(P<0.05);研究组不良反应发生率12%,较对照组(20%)低,差异无统计学意义(P>0.05)。结论普萘洛尔可提高IH治疗效果,改善患儿血管生成因子水平,且安全性高,值得推广。

Objective To study the efficacy and safety of propranolol in the treatment of infantile hemangioma(IH).Methods A total of fifty children with IH in Xiamen Children′s Hospital from January 2021 to December 2023 were selected and divided into a control group and a research group according to different treatment methods,with 25 cases in each group.The control group was treated with lauromacrogol injection,while the research group was treated with propranolol hydrochloride tablets,and the therapeutic effect of the two groups was compared.Results The total effective rate of the research group was higher than that of the control group(92%vs 68%,P<0.05);After 4 weeks and 8 weeks of treatment,the levels of angiogenic factors decreased in both groups,and the levels of vascular endothelial growth factor(VEGF)and basic fibroblast growth factor(bFGF)in the research group were significantly lower than those in the control group(P<0.05);The incidence of adverse reactions in the research group and control group were 12%and 20%,respectively,with no statistically significant difference(P>0.05).Conclusion Propranolol can improve the therapeutic effect of IH,improve the levels of angiogenic factors in children,and has high safety,which is worth promoting.