心血管衰老与神经激素信号失调

Cardiovascular aging and dysregulation of neurohormone signaling

神经激素信号是心血管衰老主要机制之一,其具体包括肾素-血管紧张素-醛固酮系统、β-肾上腺素能信号及胰岛素样生长因子-1。神经激素信号除参与心血管衰老外,还与高血压(hypertension)、心房颤动(atrial fibrillation)及心力衰竭(heart failure)等多种心血管疾病相关,两者可能存在共同机制。该文简要综述神经激素信号在心血管衰老中的作用,以期为今后心血管疾病的诊断、治疗及新药研发提供参考。

Neurohormonal signaling is one of the main mechanisms of cardiovascular aging,which specifically includes the renin-angiotensin-aldosterone system,β-adrenergic signaling,and insulin-like growth factor-1.Neurohormonal signals are not only involved in cardiovascular failure,but also associated with various cardiovascular diseases such as hypertension,atrial fibrillation,and heart failure,and there may be a common mechanism between the two.This article reviewed the role of neurohormone signaling in cardiovascular aging,aiming to provide reference for the diagnosis,treatment,and new drugs for cardiovascular diseases in the future.