针刺联合参芪地黄汤治疗气阴两虚型慢性肾小球肾炎的临床观察

Clinical observation of acupuncture combined with Shenqi Dihuang decoction in treating chronic glomerulonephritis of Qi and Yin deficiency type

目的观察针刺联合参芪地黄汤治疗气阴两虚型慢性肾小球肾炎(chronic glomerulonephritis,CGN)的临床效果。方法选择2020年10月至2024年3月于上海浦东新区公利医院确诊的CGN患者96例,随机分为治疗组和对照组,每组48例。对照组予西医基础治疗,治疗组在对照组治疗基础上予中药联合针刺治疗,均治疗8周。比较两组治疗总有效率、白介素(interleukin,IL)-2、尿红细胞、24 h尿蛋白定量(24 h urine protein quantitation,24 h UPro)、血肌酐(serum creatinine,Scr)及血尿素氮(blood urea nitrogen,BUN)水平变化情况。结果治疗后,治疗组Scr、24 h UPro及IL-2水平较前均下降(P<0.05),且治疗组低于对照组(P<0.05)。治疗组总有效率高于对照组(83.33%vs 64.58%,P<0.05)。两组均未发生明显不良反应。结论针刺联合参芪地黄汤治疗气阴两虚型CGN效果较佳,且安全性良好,作用机制可能与免疫因子调节有关。

Objective To observe the clinical effect of acupuncture combined with Shenqi Dihuang decoction in the treatment of chronic glomerulonephritis(CGN)of Qi and Yin deficiency type.Methods A total of 96 CGN patients diagnosed in Gongli Hospital of Shanghai Pudong New Area from October 2020 to March 2024 were randomly divided into treatment group and control group,with 48 cases in each group.The control group was treated with basic western medicine,and the treatment group was treated with traditional Chinese medicine combined with acupuncture for 8 weeks.The total effective rate,interleukin(IL)-2,urinary erythrocyte,24 h urinary protein quantity(24 h UPro),serum creatinine(Scr)and blood urea nitrogen(BUN)levels were compared between the two groups.Results After treatment,the levels of Scr,24 h UPro and IL-2 level in the treatment group were all decreased(P<0.05),and the treatment group was lower than the control group(P<0.05).The total effective rate of treatment group was higher than that of control group(83.33%vs 64.58%,P<0.05).There were no obvious adverse reactions in both groups.Conclusion Acupuncture combined with Shenqi Dihuang decoction is effective and safe in treating CGN of Qi and Yin deficiency type,and the mechanism of action may be related to the regulation of immune factors.