沙库巴曲缬沙坦钠片联合左西孟旦治疗射血分数降低型心力衰竭患者的效果

Effect of Sacubitril Valsartan Sodium Tablets Combined with Levosimendan in the Treatment of Patients with Low Ejection Fraction Type Heart Failure

目的:探讨沙库巴曲缬沙坦钠片联合左西孟旦治疗射血分数降低型心力衰竭患者的效果。方法:选取2021年1月-2023年12月龙口市人民医院收治的86例射血分数降低型心力衰竭患者。根据随机数表法将其均分为对照组和研究组,各43例。对照组给予沙库巴曲缬沙坦钠片,研究组在对照组基础上给予左西孟旦注射液。比较两组治疗前及治疗4周时心肌损伤标志物、心功能指标及不良反应。结果:治疗4周时,两组心肌肌钙蛋白T(cTnT)、心肌肌钙蛋白I(cTnI)、游离脂肪酸(FFA)水平均降低,研究组cTnT、FFA、cTnI水平均低于对照组,差异有统计学意义(P<0.05)。治疗4周时,两组左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)均降低,左室射血分数(LVEF)升高,研究组LVEDD、LVESD均低于对照组,LVEF高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:射血分数降低型心力衰竭患者采取沙库巴曲缬沙坦钠片联合左西孟旦治疗可有效改善心功能,效果确切。

Objective:To explore the effect of Sacubitril Valsartan Sodium Tablets combined with Levosimendan in the treatment of patients with low ejection fraction type heart failure.Method:A total of 86 patients with heart failure with reduced ejection fraction treated in Longkou People's Hospital from January 2021 to December 2023 were selected.According to the method of random number table,they were divided into control group and study group,43 cases in each group.The control group was given Sacubitril Valsartan Sodium Tablets,and the study group was given Levosimendan Injection based on the control group.Myocardial injury markers,cardiac function indexes before treatment and at 4 weeks of treatment and adverse reactions were compared between the two groups.Result:At 4 weeks of treatment,the levels of cardiac troponin T(cTnT),cardiac troponin I(cTnI)and free fatty acid(FFA)in both groups were decreased,and the levels of cTnT,FFA and cTnI in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).At 4 weeks of treatment,left ventricular end-diastolic diameter(LVEDD)and left ventricular end-systolic diameter(LVESD)were decreased in both groups,and left ventricular ejection fraction(LVEF)was increased,LVEDD and LVESD in the study group were lower than those in the control group,and LVEF was higher than that in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:In patients with low ejection fraction heart failure,Sacubitril Valsartan Sodium Tablets combined with Levosimendan can effectively improve heart function,with accurate effect.