癫痫治疗中左乙拉西坦与丙戊酸钠缓释片联合应用的效果观察

Observation on Effect of Combined Use of Levetiracetam and Sodium Valproate Sustained-release Tablets in the Treatment of Epilepsy

目的:探究癫痫治疗中左乙拉西坦与丙戊酸钠缓释片联合应用的效果。方法:选择2021年3月-2024年2月遵义市第一人民医院收治的80例癫痫患者作为研究对象,根据不同治疗方法将患者分为A组(丙戊酸钠缓释片,n=40)与B(左乙拉西坦联合丙戊酸钠缓释片,n=40)。比较两组治疗效果、癫痫症状改善情况、脑电图活动情况、认知功能及不良反应。结果:B组治疗总有效率、不良反应发生率较A组高,差异有统计学意义(P<0.05);治疗后,两组癫痫发作次数、癫痫发作持续时间较治疗前下降,且B组低于A组,差异有统计学意义(P<0.05);治疗后,两组P300潜伏期时间、20 min内痫样放电次数及30 s内δ波、θ波次数较治疗前下降,且B组低于A组,两组30 s内α波次数较治疗前上升,且B组高于A组,差异有统计学意义(P<0.05);治疗后,两组简易精神状态量表(MMSE)评分较治疗前升高,且B组高于A组,差异有统计学意义(P<0.05)。结论:癫痫联合应用左乙拉西坦、丙戊酸钠缓释片治疗,可提升治疗效果,改善癫痫发作症状、脑电波活动,改善认知功能,尽管会增加药物不良反应发生率,但患者对不良反应基本耐受,并未影响治疗过程。

Objective:To explore the effect of combined use of Levetiracetam and Sodium Valproate Sustained-release Tablets in the treatment of epilepsy.Method:A total of 80 patients with epilepsy who admitted to the First People's Hospital of Zunyi City from March 2021 to February 2024 were selected as the research objects,the patients were divided into group A(Sodium Valproate Sustained-Release Tablets,n=40)and group B(Levetiracetam combined with Sodium Valproate Sustained-Release Tablets,n=40)according to different treatment methods.The therapeutic effect,improvement of epilepsy symptoms,electroencephalogram activity,cognitive function and adverse reactions were compared between two groups.Result:The total effective rate and the incidence of adverse reactions in group B were higher than those in group A,and the differences were statistically significant(P<0.05);after treatment,the number of seizures and the duration of seizures in two groups were lower than those before treatment,and those in group B were lower than those in group A,the differences were statistically significant(P<0.05);after treatment,the latency time of P300,the number of epileptiform discharges within 20 min,the number ofδwave andθwave within 30 s in two groups were lower than those before treatment,and those in group B were lower than those in group A,the number ofαwave within 30 s in two groups were higher than those before treatment,and that in group B was higher than that in group A,the differences were statistically significant(P<0.05);after treatment,the scores of mini-mental state examination(MMSE)in two groups were higher than those before treatment,and that in group B were higher than that in group A,the differences were statistically significant(P<0.05).Conclusion:Epilepsy combined with Levetiracetam and Sodium Valproate Sustained-release Tablets can improve the therapeutic effect,improve the symptoms of epileptic seizures,brain wave activity,and improve cognitive function,although it will increase the incidence of adverse drug reactions,patients are basically tolerant of adverse reactions and do not affect the treatment process.