芪苈强心胶囊联合达格列净应用于老年HFpEF治疗的效果

Effect of Qili Qiangxin Capsules Combined with Dapagliflozin in the Treatment of Elderly HFpEF

目的:探究芪苈强心胶囊联合达格列净应用于老年射血分数保留型心力衰竭(HFpEF)治疗的效果。方法:选取2022年1月-2024年1月沂南县人民医院收治的120例老年HFpEF患者作为研究对象。根据信封法将其随机分为联合组和对照组,各60例。两组均给予常规抗心衰治疗,对照组给予达格列净,联合组在对照组基础上给予芪苈强心胶囊。比较两组临床疗效,治疗前后心脏舒张功能、运动耐力、生活质量及不良反应。结果:联合组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组脑钠肽(BNP)、左室舒张末期内径(LVEDD)、左房内径(LAD)、左心房容积指数(LAVI)、左心室质量指数(LVMI)和左心室舒张早期二尖瓣血流最大速度(E)/舒张早期二尖瓣环峰值速度(e')均降低,联合组均低于对照组,两组左室射血分数(LVEF)升高,联合组LVEF高于对照组,差异有统计学意义(P<0.05)。治疗后,两组6分钟步行试验(6MWT)距离升高,明尼苏达心力衰竭生活质量问卷(MLHFQ)评分降低,联合组6MWT距离高于对照组,MLHFQ评分低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:老年HFpEF给予芪苈强心胶囊联合达格列净治疗,可提升治疗效果,改善心脏舒张功能,提高运动耐力及生活质量。

Objective:Exploring the efficacy of Qili Qiangxin Capsules combined with Dapagliflozin in the treatment of elderly patients with ejection fraction preserved heart failure(HFpEF).Method:120 elderly patients with HFpEF who underwent treatment at Yinan County People's Hospital from January 2022 to January 2024 were selected as the study subjects.The patients were randomly divided into combination group and control group.Both groups were treated with conventional anti heart failure therapy.On this basis,the control group was treated with Dapagliflozin,while the combination group was treated with Qili Qiangxin Capsules in addition to the control group.The therapeutic effects of two groups was compared.Result:The total effective rate of the combined group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of brain natriuretic peptide(BNP),left ventricular end diastolic diameter(LVEDD),left atrial diameter(LAD),left atrial volume index(LAVI),left ventricular mass index(LVMI),and maximum velocity(E)/peak velocity(e')of early diastolic mitral valve blood flow in both groups decreased,and the combined group was lower than the control group,the left ventricular ejection fraction(LVEF)levels of both groups increased,and the combined group was higher than that of the control group,the differences were statistically significant(P<0.05).After treatment,the 6-minute walking test(6MWD)distance levels of both groups of patients increased,the Minnesota heart failure quality of life questionnaire(MLHFQ)score was decreased,the 6MWT distance of the combined group was higher than that of the control group,and the MLHFQ score was lower than that of the control group,the differences were statistically significant(P<0.05).the differences were statistically significant(P<0.05).There was no statistically significant difference in adverse reactions between the two groups(P>0.05).Conclusion:The treatment of Qili Qiangxin Capsules combined with Dapagliflozin in elderly HFpEF can improve the diastolic function of the heart,and enhance the exercise endurance and quality of life.