瑞芬太尼复合丙泊酚在脑肿瘤切除术中的麻醉效果与安全性研究

Study on Anesthetic Effect and Safety of Remifentanil Combined with Propofol in Brain Tumor Resection Surgery

目的:探究瑞芬太尼复合丙泊酚在脑肿瘤切除术中的麻醉效果与安全性。方法:回顾性分析2022年6月-2023年6月新疆医科大学第一附属医院收治的102例脑肿瘤切除术患者的临床资料,根据麻醉方式不同将患者分为对照组(n=51,接受瑞芬太尼复合丙泊酚静脉维持麻醉)与观察组(n=51,接受瑞芬太尼复合丙泊酚静吸复合维持麻醉),比较两组插管前(T_(0))、插管后5 min(T_(1))、切皮时(T_(2))、钻孔时(T_(3))、硬膜剪开始时(T_(4))和术毕(T_(5))血流动力学指标[平均动脉压(MAP)、心率(HR)、脑电双频指数(BIS)]、苏醒时间、拔管时间、胃肠道恢复时间、住院时间及神经重症监护室(NCU)停留时间及不良反应。结果:两组T_(0)、T_(1)、T_(2)、T_(3)、T_(4)和T_(5)的MAP、HR及BIS比较,差异无统计学意义(P>0.05)。观察组苏醒时间、拔管时间早于对照组,差异有统计学意义(P<0.05);两组胃肠道恢复时间、住院时间及NCU停留时间比较,差异无统计学意义(P>0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:瑞芬太尼复合丙泊酚在脑肿瘤切除术中显示出良好的麻醉效果与安全性,更早的苏醒及拔管时间,且不增加不良反应发生率。

Objective:To investigate the anesthetic effect and safety of Remifentanil combined with Propofol in brain tumor resection surgery.Method:The clinical data of 102 patients with brain tumor resection surgery who admitted to the First Affiliated Hospital of Xinjiang Medical University from June 2022 to June 2023 were retrospectively analyzed,the patients were divided into the control group(n=51,receiving Remifentanil combined with Propofol intravenous anesthesia)and the observation group(n=51,receiving Remifentanil combined with Propofol intravenous anesthesia)according to different anesthesia methods.The hemodynamic indexes[mean arterial pressure(MAP),heart rate(HR),bispectral index(BIS)]before intubation(T_(0)),5 min after intubation(T_(1)),skin incision(T_(2)),drilling(T_(3)),dural shears(T_(4))and at the end of operation(T_(5)),recovery time,extubation time,gastrointestinal recovery time,hospitalization time,Neurological Care Unit(NCU)stay time and adverse reactions were compared between two groups.Result:There were no significant differences in the MAP,HR and BIS between two groups at T_(0),T_(1),T_(2),T_(3),T_(4)and T_(5)(P>0.05).The recovery time and extubation time of the observation group were earlier than those of the control group,and the differences were statistically significant(P<0.05);there were no significant differences in the gastrointestinal recovery time,hospitalization time and NCU stay time between two groups(P>0.05).There was no significant difference in the incidence of adverse reactions between two groups(P>0.05).Conclusion:Remifentanil combined with Propofol show good anesthetic effect and safety in brain tumor resection surgery,with earlier recovery and extubation time,and do not increase the incidence of adverse reactions.