壮肾固精方治疗IgA肾病的临床效果观察

Clinical Effect of Zhuangshen Gujing Prescription in the Treatment of IgA Nephropathy

目的:评估壮肾固精方治疗IgA肾病的临床效果。方法:选取2021年12月-2023年10月广东省中医院珠海医院门诊收治的71例IgA肾病患者作为观察对象。所有患者均给予壮肾固精方及基础治疗。比较所有患者治疗前后中医症候积分、实验室指标。统计治疗后临床疗效、中医症候疗效及安全性。结果:治疗后,24 h尿蛋白定量、尿微量白蛋白/尿肌酐、中医症候评分较治疗前下降,估算肾小球滤过率(eGFR)明显高于治疗前,差异有统计学意义(P<0.05)。结论:壮肾固精方对降低IgA肾病的尿蛋白具有显著作用,且安全性好。

Objective:To evaluate the clinical effect of Zhuangshen Gujing Prescription in the treatment of IgA nephropathy.Method:A total of 71 patients with IgA nephropathy admitted to the Outpatient Department of Zhuhai Hospital of Guangdong Provincial Hospital of Traditional Chinese Medicine from December 2021 to October 2023 were selected as the observation objects.All patients were given Zhuangshen Gujing Prescription and basic treatment.The scores of chinese medicine symptoms and laboratory indexes of all patients were compared before and after treatment.The clinical efficacy,chinese medicine syndrome efficacy and safety were counted.Result:After treatment,24 h urinary protein quantity,urinary microalbumin/urinary creatinine and chinese medicine symptom score decreased compared with before treatment,estimate glomerular filtration rate(eGFR)was significantly higher than that before treatment,the difference was statistically significant(P<0.05).Conclusion:Zhuangshen Gujing Prescription has a significant effect on reducing urinary protein in IgA nephropathy,and it is safe.