摘要
Background:To summarize the diagnosis and treatment of a patient with nasopharyngeal carcinoma and cere-brospinal fluid(CSF)Epstein-Barr virus(EBV)positivity(determined by next-generation sequencing),review the relevant literature,and explore the significance of EBV presence in the CSF of patients with nasopharyngeal carcinoma.Methods:A patient presenting with headache as the initial symptom was diagnosed with nasopharyngeal carci-noma and admitted to the Eighth Medical Center of Chinese PLA General Hospital on March 3,2021.Available databases were screened for reports on nasopharyngeal carcinoma with EBV-positive CSF and analyzed.The patients’general information,initial symptoms,treatment,and prognosis were subsequently evaluated.Results:EBV-positive CSF is commonly observed in patients with recurrent nasopharyngeal carcinoma.However,no reports of EBV-positive CSF in patients with primary nasopharyngeal carcinoma have been published to date.Conclusion:The presence of EBV in the CSF of patients with recurrent nasopharyngeal carcinoma is indicative of a poor prognosis.Thus,newly diagnosed nasopharyngeal carcinoma patients should undergo a lumbar puncture as soon as possible to have their CSF tested for EBV.Such a measure would promptly predict the prognosis and facilitate the development of a personalized treatment strategy.
基金
supported by the Key Project of the Eighth Medical Center of PLA General Hospital(No.2021ZD007,2021).
