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Augmenting osteoporotic bone regeneration through a hydrogel-based rejuvenating microenvironment

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摘要 Osteoporotic bone defects pose a significant challenge for bone regeneration as they exhibit impaired healing capacity and delayed healing period.To address this issue,this study introduces a hydrogel that creates a rejuvenating microenvironment,thereby facilitating efficient bone repair during the initial two weeks following bone defect surgery.The hydrogel,named GelHFS,was created through host-guest polymerization of gelatin and acrylatedβ-cyclodextrin.Incorporation of the human fetal mesenchymal stem cell secretome(HFS)formed GelHFS hydrogel aimed at mimicking a rejuvenated stem cell niche.Our results demonstrated that GelHFS hydrogel promotes cell stellate spreading and osteogenic differentiation via integrinβ1-induced focal adhesion pathway.Implantation of GelHFS hydrogel in an osteoporotic bone defect rat model recruited endogenous integrinβ1-expressing cells and enhanced new bone formation and bone strength.Our findings reveal that GelHFS hydrogel provides a rejuvenating niche for endogenous MSCs and enhances bone regeneration in osteoporotic bone defect.These findings highlight the potential of GelHFS hydrogel as an effective therapeutic strategy for addressing challenging bone healing such as osteoporotic bone regeneration.
出处 《Bioactive Materials》 SCIE CSCD 2024年第11期440-454,共15页 生物活性材料(英文)
基金 National Natural Science Foundation of China(82172430 and 82272505) University Grants Committee,Research Grants Council of the Hong Kong Special Administrative Region,China(14113723,14108720,14121721,14202920,N_CUHK472/22,C7030-18G,T13-402/17-N and AoE/M-402/20) Heath and Medical Research Fund(HMRF)Hong Kong(17180831,08190416 and 09203436) Hong Kong Innovation Technology Commission Funds(PRP/050/19FX),CUHK direct grant(2022.042).
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