间苯三酚与山莨菪碱对急诊肾绞痛患者疗效与安全性研究

Comparative Study on the Efficacy and Safety of Phloroglucinol and Anisodamine in Emergency Treatment of Renal Colic

目的比较间苯三酚与山莨菪碱在治疗急性肾绞痛患者中的疗效和安全性。方法选取2021年1月至2023年1月在福建中医药大学附属第三人民医院就诊的126例肾绞痛患者为研究对象。根据随机数字表法,分为观察组(间苯三酚+氟比洛芬酯)和对照组(山莨菪碱+氟比洛芬酯),每组63例,比较临床疗效情况、疼痛程度、镇痛的时效性以及不良反应发生情况。结果观察组研究对象的临床有效率为96.83%,显著高于对照组的79.37%,差异有统计学意义(P=0.003)。治疗前,两组研究对象疼痛程度VAS评分无显著差异(P>0.05)。治疗后,两组研究对象VAS评分均较治疗前显著降低(P值均<0.001),且观察组研究对象的VAS评分显著低于对照组(P<0.001)。观察组研究对象镇痛起效时间和疼痛缓解时间均显著短于对照组(P值均<0.001)。观察组研究对象的不良反应总发生率为7.94%,显著低于对照组的22.22%。结论与山莨菪碱相比,间苯三酚用于治疗急性肾绞痛临床疗效显著,可有效缓解患者疼痛,镇痛时效性和安全性相对较高。

Objective To compare the efficacy and safety of phloroglucinol versus anisodamine in the treatment of patients with acute renal colic.Methods A total of 126 patients with renal colic,who were treated at the Third People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine from January 2021 to January 2023,were included for the study.Using a random number table method,the patients were divided into an observation group(phloroglucinol+flurbiprofen ester)and a control group(anisodamine+flurbiprofen ester),with 63 patients in each group.The clinical efficacy,pain intensity,analgesic onset time,and incidence of adverse reactions were compared between the two groups.Results The clinical effective rate in the observation group was 96.83%,significantly higher than the 79.37%in the control group,with a statistically significant difference(P=0.003).There was no significant difference in the baseline VAS pain scores(P>0.05).After treatment,the VAS pain scores in both groups were significantly lower than before treatment(both P<0.001),and the scores in the observation group were significantly lower than those in the control group(P<0.001).The analgesic onset time(P<0.001)and pain relief time(P<0.001)in the observation group were significantly shorter than those in the control group.The total incidence of adverse reactions in the observation group was 7.94%,significantly lower than the 22.22%in the control group.Conclusion Compared with anisodamine,phloroglucinol has a significant clinical efficacy in treating patients with acute renal colic.It effectively alleviates pain,with better analgesic onset and safety profile.