期刊文献+

Eudesmane-guaiane sesquiterpenoid dimers from Aucklandia cos-tus trigger paraptosis-like cell death via ROS accumulation and MAPK hyperactivation

原文传递
导出
摘要 Three novel sesquiterpenoid heterodimers,designated as auckcostusolides A-C(1-3),were isolated from Aucklandia costus leaves.The structures of compounds 1-3 were elucidated through comprehensive spectroscopic analysis,with their absolute configurations established using a combination of X-ray single-crystal diffraction and electronic circular dichroism(ECD)calculations.Notably,compounds 1 and 2,despite sharing identical planar structures derived from two identical sesquiterpenoids,exhibited oppos-ite configurations at C-11 and C-8'.This configurational difference can be attributed to distinct Diels-Alder cycloaddition processes between the sesquiterpenoid monomers.Additionally,the cytotoxic effects of compounds 1-3 were evaluated against colorectal can-cer HCT116 cells,fibrosarcoma HT1080 cells,and hepatocellular carcinoma HepG2 cells.Compounds 1-3 induced cell death was characterized by endoplasmic reticulum(ER)swelling and cytoplasmic vacuolization,typical morphological changes associated with paraptosis.Mechanistic studies revealed that compounds 1 and 3 triggered paraptosis-like cell death through the accumulation of react-ive oxygen species(ROS),activation of ER stress,and stimulation of the MAPK signaling pathway.
出处 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2024年第11期1011-1019,共9页 中国天然药物(英文版)
基金 supported by Yunnan RevitalizationTalentSupport Program“Top Team”Project(No.202305AT350001) “Young Talent”Project(No.YNQR-QNRC-2019-091) the National Natural Science Foundation of China(Nos.32170408,32000280,and 32000548) the Ten Thousand Talents Plan of Yunnan Province for Industrial Technology Leading Talents(No.YNWR-CYJS-2019-011) the Project of Yunnan Characteristic Plant Screening and R&D Service CXO Platform(No.2022YKZY001) the CAS Pioneer Hundred Talents Program,the Training of Technological Innovation Talents of Yunnan Province(No.202305AD160009) the Special Research Assistant of Chinese Academy of Sciences(No.E3292211Q1) the Young Academic and Technical Leader Raising Foundation of Yunnan Province(No.202005AC160035).
  • 相关文献

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部