摘要
The nitrile compounds are present in a variety of biologically active natural products and pharmaceuticals,and the nitrile groups are versatile synthetic intermediates to other functionalized compounds.Herein,the asymmetric reduction ofα,β-unsaturated nitriles with water as a hydrogen source is reported.The reaction is catalyzed by the complex of[Ir(COD)Cl]_(2)and(R_(a),S)-Ph-Bn-SiPhox,and allows the preparation of useful enantioenriched chiral 3,3-disubstituted propionitriles with high optical purities in mild conditions.
基金
grateful to the National Natural Science Foundation of China(Nos.21961045 and 22061048)
the Basic Research Project of Chongqing Academy of Chinese Materia Medica(No.jbky20190028)
the Fund Project of Yunnan Key Laboratory of Pharmacology for Natural Products(No.YKLPNP-K2303)
Yunnan Provincial Key Laboratory Construction Plan Funding of Universities
Yunnan Provincial Engineering Research Center Construction Plan Funding of Universities for their financial support.
