Rhodium/Ming-Phos-catalyzed asymmetric annulation reaction of silacyclobutanes with terminal alkynes

Asymmetric ring-expansion reactions of silacyclobutanes(SCBs)with alkynes have evolved as one of the powerful protocols for the construction of silicon-stereogenic compounds.However,the achievement of highly enantioselective annulation of SCBs with terminal alkynes remains a challenge.Herein,we report a rhodium-catalyzed asymmetric annulation reaction of SCBs with terminal alkynes,which relies on the newly identified chiral sulfinamide phosphine ligand Ming-Phos.This catalytic system exhibits unique effects under mild conditions,leading to the direct synthesis of structurally diverse chiral silacycles in moderate to good yields with high enantioselectivities(up to 95%ee).