系统免疫炎症指数与新发高尿酸血症相关性的队列研究

Association of systemic immunity-inflammation index with the risk of hyperuricemia:A cohort study

目的探讨系统免疫炎症指数(SII)与高尿酸血症(HUA)的相关性。方法以2014年1月至2022年12月在大连医科大学附属第二医院健康管理中心至少进行3次健康体检的受检者为研究对象并构建动态队列。以中性粒细胞、血小板、淋巴细胞计数构建反映机体炎症状态的SII,采用Cox比例风险回归模型探讨总人群及不同亚组人群中SII和HUA的关联,并进行了2次敏感性分析。结果研究共纳入20022名研究对象,平均随访时间3.67年,校正混杂因素后,连续变量lnSII每增加1个单位,HUA的发生风险增加24%(HR=1.24,95%CI 1.16~1.32,P<0.001)。SII作为分类变量,与最低四分位数(Q 1)组相比,总人群中Q 2、Q 3、Q 4组发生HUA的风险分别增加了12%(HR=1.12,95%CI 1.03~1.21,P=0.006)、14%(HR=1.14,95%CI 1.06~1.24,P=0.001)、27%(HR=1.27,95%CI 1.17~1.37,P<0.001)。各亚组分析和敏感性分析均显示SII与HUA具有正相关关系。结论SII水平升高能显著增加HUA的发病风险,利用SII评估机体炎症状态将有助于对HUA高危人群进行风险筛查和预防管理。

ObjectiveTo explore the correlation between systemic immunity-inflammation index(SII)and hyperuricemia(HUA).MethodsParticipants who had at least 3 health checkups in the Health Management Center of the Second Affiliated Hospital of Dalian Medical University from January 2014 to December 2022 were selected to construct a dynamic cohort.The SII,reflecting the inflammatory state of the body,was constructed using neutrophil,platelet,and lymphocyte counts.A Cox proportional hazard regression model was used to explore the association between SII and HUA in the overall population and different subgroups of the population,and sensitivity analysis was performed twice.ResultsA total of 20022 subjects were included,and the mean follow-up time was 3.67 years.After adjusting for confounding factors,each unit increase in the natural logarithm of SII(lnSII)was associated with a 24%increased risk of hyperuricemia(HR=1.24,95%CI 1.16-1.32,P<0.001).As a categorical variable,compared with the lowest quartile array(Q 1),the risk of HUA in the total population increased by 12%(HR=1.12,95%CI 1.03-1.21,P=0.006),14%(HR=1.14,95%CI 1.06-1.24,P=0.001),27%(HR=1.27,95%CI 1.17-1.37,P<0.001)in Q 2,Q 3 and Q 4 groups within the general population,respectively.All subgroup analysis and sensitivity analysis showed that SII was positively correlated with HUA.ConclusionsElevated levels of SII significantly increase the risk of HUA.Assessing the body′s inflammatory status using SII can aid in risk screening and preventive management for individuals at high risk of HUA.