TyG指数联合单核细胞与高密度脂蛋白胆固醇比值与2型糖尿病患者冠状动脉病变严重程度的相关性研究

Correlation of TyG index combined with monocyte-to-high-density lipoprotein cholesterol ratio and severity of coronary artery lesions in patients with type 2 diabetes mellitus

2型糖尿病患者通常具有更高的包括冠状动脉疾病(CAD)在内的心血管疾病风险,目前用于诊断2型糖尿病患者冠状动脉病变严重程度的金标准是行冠状动脉造影(CAG)检查。本文回顾性分析了2020年5月至2022年7月在衡水市人民医院诊治的行CAG的2型糖尿病患者数据,通过多元logistic回归分析确定了与2型糖尿病患者冠状动脉狭窄程度相关的因素,并基于这些因素建立了诊断2型糖尿病患者冠状动脉病变严重程度的预测模型:吸烟史、偏高的三酰甘油葡萄糖乘积(TyG)指数和单核细胞/高密度脂蛋白胆固醇比值(MHR)。其中TyG指数联合MHR诊断模型可在一定程度上反映2型糖尿病患者冠状动脉狭窄的严重程度,避免非必要的侵入性CAG。

Patients with type 2 diabetes mellitus(T2DM)typically have a higher risk of cardiovascular diseases,including coronary artery disease(CAD).Currently,the gold standard for diagnosing the severity of coronary artery lesions in T2DM patients is coronary angiography(CAG).This retrospective analysis reviewed data from T2DM patients who underwent CAG at Hengshui People′s Hospital between May 2020 and July 2022.Utilizing multivariate logistic regression analysis,factors associated with the severity of coronary artery stenosis in T2DM patients were identified.Based on these findings,a predictive model was developed to evaluate CAD severity in T2DM patients,incorporating smoking history,elevated triglyceride-glucose(TyG)index,and elevated monocyte to high-density lipoprotein cholesterol ratio(MHR).The combination of the TyG index and MHR model provides insights into coronary artery stenosis severity in T2DM patients,potentially reducing unnecessary invasive CAG procedures.