针刺治疗急性心肌缺血机制研究进展

Research Progress on Mechanism of Acupuncture Treatment for AMI

急性心肌缺血(AMI)是心血管疾病中最常见且风险系数较高的疾病,严重时可危及生命。研究表明,针刺对AMI具有良好的防治效果,但其潜在作用机制尚不甚明确,且相关工作的梳理较少。为此,本研究以神经-内分泌-免疫(NEI)网络为切入点,针对穴位启动、传入、中枢、传出及效应器官等多个环节介绍了相关研究成果。结果发现,针刺信号通过神经系统、内分泌系统与免疫系统之间生物学信号的不断双向反馈实现逐级传递、级联放大,并最终起到防治急性心肌缺血的作用。基于此,本研究建议开展多学科融合研究,对针刺起效过程中的各个环节及整体通路进行系统研究,为进一步扩宽研究角度、拓展临床治疗思路奠定基础。

Acute myocardial ischemia(AMI)is the most common and high-risk cardiovascular disease,which may be fatal in urgent cases.Studies have shown that acupuncture has been widely utilized as an effective therapy in treatment of AMI.However,its potential mechanism of action is not yet well understood,and there has been little review of related work.Therefore,this study uses the neural-endocrine-immune(NEI)network as a starting point to introduce relevant research findings on various aspects such as acupoint activation,afferent pathways,central processing efferent pathways,and effector organs.The results showed that acupuncture signals are transmitted step by step and amplified in a cascade through continuous bidirectional feedback among the nervous,endocrine and immune systems,ultimately preventing AMI.Based on this,this study suggests conducting multidisciplinary research to systematically study the various stages and overall pathways involved in the acupuncture effect process,laying the foundation for broadening research perspectives and expanding clinical treatment approaches.