针刺治疗糖尿病的分子生物学机制研究进展

Research progress in molecular mechanism of acupuncture for diabetes mellitus

从分子生物学的视角探讨针刺治疗糖尿病的作用机制,旨在揭示其促进身体恢复平衡及对抗糖尿病的潜在规律。通过检索针刺治疗糖尿病相关分子生物学机制的研究文献,发现其分子生物学机制与胰岛素信号通路的调节、炎性反应的调控、胰岛β细胞的保护与再生以及脂肪代谢和能量平衡密切相关。目前尚缺乏针刺对1型糖尿病相关研究及大规模随机对照试验,以及对其上游调控机制、细胞分子以及各分子间相互作用机制的研究。针刺治疗糖尿病的分子生物学机制仍需要多层次、多靶点、多维度的深入探索。

This paper discusses the mechanism of acupuncture for diabetes mellitus from the perspective of molecular biology,aiming to reveal the potential rules of restoring the balance in the body and fighting against diabetes mellitus(DM).By searching the basic research literature of acupuncture treatment for DM,it is found that the molecular biological mechanism of acupuncture treatment for DM is closely related to the regulation of insulin signaling pathway,the modulation of inflammatory response,the protection and regeneration of isletβ-cells,fat metabolism and energy balance.It points out that there are few studies of acupuncture on the type 1 diabetes mellitus and the large-scale randomized controlled trials,as well as the studies on the upstream regulation mechanism,the specific cellular molecules and the interaction mechanism of various molecules.It needs to deepen the multi-level,multi-target and multi-dimensional exploration on the molecular biological mechanism of acupuncture for diabetes mellitus.