德谷胰岛素联合阿卡波糖治疗老年糖尿病的效果分析

Effect of Degu Insulin Combined with Acarbose in the Treatment of Senile Diabetes Mellitus

目的:分析德谷胰岛素联合阿卡波糖治疗老年糖尿病的效果。方法:选取2021年1月—2023年6月如皋市第三人民医院收治的糖尿病患者71例作为研究对象,随机分为对照组(35例)和观察组(36例)。对照组给予阿卡波糖治疗,观察组在对照组基础上给予德谷胰岛素治疗。比较两组治疗效果。结果:治疗后,两组空腹血糖、餐后2 h血糖、糖化血红蛋白、空腹胰岛素、胰岛素抵抗指数低于治疗前,且观察组低于对照组(P<0.05)。治疗后,两组脂联素水平高于治疗前,且观察组高于对照组,两组抵抗素、瘦素水平低于治疗前,且观察组低于对照组(P<0.05)。治疗后,两组双歧杆菌、拟杆菌数量高于治疗前,且观察组高于对照组,两组肠杆菌、肠球菌数量低于治疗前,且观察组低于对照组(P<0.05)。观察组满意度高于对照组(P=0.017)。结论:德谷胰岛素联合阿卡波糖治疗老年糖尿病的效果显著,可降低血糖、胰岛代谢指标水平,改善脂肪因子水平、菌群数量,提高患者满意度。

Objective:To analyze the effect of Degu insulin combined with acarbose on senile diabetes mellitus.Methods:A total of seventy-one diabetic patients admitted to Rugao Third People's Hospital from January 2021 to June 2023 were selected as the study objects,and randomly divided into control group(35 cases)and observation group(36 cases).The control group was treated with acarbose,and the observation group was treated with Degu insulin on the basis of control group.The therapeutic effect of the two groups was compared.Results:After treatment,fasting blood glucose,2 h postprandial blood glucose,glycated hemoglobin,fasting insulin and insulin resistance index in both groups were lower than before treatment,and observation group was lower than control group(P<0.05);after treatment,adiponectin levels in two groups were higher than before treatment,and observation group was higher than control group,resistin and leptin levels in two groups were lower than before treatment,and observation group was lower than control group(P<0.05);after treatment,the number of bifidobacteria and bacteroides in two groups was higher than before treatment,and the observation group was higher than the control group,the number of enterobacteria and enterococcus in two groups was lower than before treatment,and the observation group was lower than the control group(P<0.05);the satisfaction of observation group was higher than that of control group(P=0.017).Conclusion:The effect of Deglu insulin combined with acarbose is significant in the treatment of elderly diabetes mellitus,which can reduce the level of blood glucose and islet metabolism index,improve the level of adipokine and the number of bacteria,and improve patient satisfaction.