透明细胞性肾细胞癌与乳头状肾细胞癌的临床病理特点 免疫组化特征和预后分析

Clinicopathological Features Immunohistochemical Features and Prognosis of Clear Cell Renal Cell Carcinoma and Papillary Renal Cell Carcinoma

目的:分析透明细胞性肾细胞癌(CCRCC)与乳头状肾细胞癌(PRCC)的临床病理特点、免疫组化特征和预后。方法:回顾性分析2021年4月至2023年4月我院收治的80例肾细胞癌患者临床资料,按照病理结果将其分为CCRCC组(n=50)与PRCC组(n=30),对比两组患者基础资料、临床病理特点和免疫组化特征。所有患者均进行手术治疗且有出院后随访,统计并比较两组患者术后1年生存情况。结果:CCRCC组患者血尿比率低于PRCC组(P<0.05)。CCRCC组肿瘤直径、T分期、N分期、M分期、侵犯肾包膜和Fuhrman分级与PRCC组比较差异均无统计学意义(P>0.05)。CCRCC组CD10阳性率高于PRCC组(P<0.05),CK7阳性率低于PRCC组(P<0.05),PAX-8阳性率、TFE-3阳性率、Vimentin阳性率与PRCC组比较差异均无统计学意义(P>0.05)。CCRCC组术后1年生存情况与PRCC组比较差异无统计学意义(P>0.05)。结论:CCRCC与PRCC患者存在血尿和免疫组化CD10、CK7阳性表达差异,其短期预后相近。

Objective:To analyze the clinicopathological features,immunohistochemical features and prognosis of clear cell renal cell carcinoma(CCRCC)and papillary renal cell carcinoma(PRCC).Methods:The clinical data of 80 patients with renal cell carcinoma in the hospital from April 2021 to April 2023 were retrospectively analyzed.According to the pathological results,the patients were divided into CCRCC group(n=50)and PRCC group(n=30).The basic data,clinicopathological features and immunohistochemical features were compared between the two groups.All patients received surgical treatment and were followed up after discharge.The survival status at 1 year after surgery was counted and compared.Results:The hematuria ratio in CCRCC group was lower than that in PRCC group(P<0.05).There were no statistical differences in tumor diameter,T staging,N staging,M staging,renal envelope invasion and Fuhrman grading between CCRCC group and PRCC group(P>0.05).The positive rate of CD10 in CCRCC group was higher than that in PRCC group(P<0.05)while the positive rate of CK7 was lower than that in PRCC group(P<0.05),but the positive rates of PAX-8,TFE-3 and Vimentin revealed no statistical differences between CCRCC group and PRCC group(P>0.05).There was no statistical significance in survival status at 1 year after surgery in CCRCC group compared to PRCC group(P>0.05).Conclusion:There are differences in hematuria and immunohistochemical CD10 and CK7 positive expressions between CCRCC patients and PRCC patients,and the short-term prognosis is similar.