心力衰竭患者血清Pro-BNP心电图QRS波时限与心脏超声参数的关系研究

Correlation between Serum Pro-BNP Electrocardiogram QRS Wave Duration and Cardiac Ultrasound Parameters in Patients with Heart Failure

目的:研究心力衰竭患者血清脑钠肽前体(Pro-BNP)、心电图QRS波时限与心脏超声参数的关系。方法:选取2023年1月至2024年3月我院收治的104例心力衰竭患者作为研究对象,另选择同期住院心功能正常的30例患者作为对照组,两组均进行血清Pro-BNP检测、心电图检查和超声心动图检查,对比两组血清Pro-BNP水平、QRS波群时限和心脏超声参数[左心室射血分数(LVEF)、左室舒张末期容积(LVEDV)和左室收缩末期容积(LVESV)];根据心功能评估情况、预后情况将心力衰竭患者分为Ⅰ~Ⅱ级组和Ⅲ~Ⅳ级组、预后良好组和预后不良组,对比Ⅰ~Ⅱ级组和Ⅲ~Ⅳ级组、预后良好组和预后不良组血清Pro-BNP水平、QRS波群时限和心脏超声参数;并对心力衰竭患者这些指标间的关系进行Pearson相关性分析。结果:心力衰竭组血清Pro-BNP水平、QRS波群时限、LVEDV及LVESV均大于对照组(P<0.05),LVEF小于对照组(P<0.05)。心功能Ⅲ~Ⅳ级组血清Pro-BNP水平、QRS波群时限、LVEDV及LVESV均大于Ⅰ~Ⅱ级组(P<0.05),LVEF小于Ⅰ~Ⅱ级组(P<0.05)。预后不良组血清Pro-BNP水平、QRS波群时限、LVEDV及LVESV均大于预后良好组(P<0.05),LVEF小于预后良好组(P<0.05)。心力衰竭患者血清Pro-BNP水平与QRS波群时限、LVEDV及LVESV均呈正相关性(P<0.05),与LVEF呈负相关性(P<0.05);QRS波群时限与LVEDV、LVESV均呈正相关性(P<0.05),与LVEF呈负相关性(P<0.05)。结论:心力衰竭患者血清Pro-BNP水平、心电图QRS波群时限与心脏超声参数之间存在明显相关性,且这些指标均与患者病情和预后有关。

Objective:To study the relationship between serum pro-brain natriuretic peptide(Pro-BNP),electrocardiogram QRS wave duration,and cardiac ultrasound parameters in patients with heart failure(HF).Methods:Totally 104 patients with HF in the hospital were selected from January 2023 to March 2024 as the study subjects,and 30 patients with normal cardiac function during the same period were made the control group.Serum Pro-BNP detection,electrocardiogram examination and echocardiography were performed in both groups.The two groups were compared in terms of serum Pro-BNP level,QRS wave duration and cardiac ultrasound parameters[left ventricular ejection fraction(LVEF),LVEDV and LVESV].According to the cardiac function evaluation status and prognosis status,patients with HF were divided into grade I-II group,grade III-IV group,good prognosis group,and poor prognosis group.Serum Pro-BNP level,QRS wave duration and cardiac ultrasound parameters were compared between grade I-II group and grade III-IV group and between good prognosis group and poor prognosis group.Pearson correlation analysis was performed on the relationship between these indicators in patients with HF.Results:Serum Pro-BNP level,QRS wave duration,LVEDV and LVESV in the heart failure group were higher(P<0.05)while LVEF was lower than in the control group(P<0.05).Serum Pro-BNP level,QRS wave duration,LVEDV and LVESV in cardiac function grade III-IV group were higher(P<0.05)while LVEF was lower compared to grade I-II group(P<0.05).The level of serum Pro-BNP,QRS wave duration,LVEDV and LVESV in the poor prognosis group were higher than in the good prognosis group(P<0.05)while the LVEF was lower(P<0.05).Serum Pro-BNP level in patients with HF was positively correlated with QRS wave duration,LVEDV and LVESV(P<0.05),and was negatively correlated with LVEF(P<0.05).QRS wave duration was positively associated with LVEDV and LVESV(P<0.05),and inversely related to LVEF(P<0.05).Conclusion:There is a significant correlation between serum Pro-BNP level,electrocardiogram QRS wave duration and cardiac ultrasound parameters in patients with heart failure,and the above indicators are associated with the disease condition and prognosis of patients.