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Revealing the regulation of water dipole potential to aggregation of amyloid-β42 at chiral interface by surface-enhanced infrared absorption spectroscopy

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摘要 Surface chirality plays an important role in determining the biological effect,but the molecular nature beyond stereoselectivity is still unknown.Herein,through surface-enhanced infrared absorption spectroscopy,electrochemistry,and theoretical simulations,we found diasteromeric monolayers induced by assembled density on chiral gold nanofilm and identified the positive contribution of water dipole poten-tial at chiral interface and their different interfacial interactions,which result in a difference both in the positive dipoles of interfacial water compensating the negative surface potential of the SAM and in the hindrance effect of interface dehydration,thereby regulating the interaction between amyloid-βpeptide(Aβ)and N-isobutyryl-cysteine(NIBC).Water on L-NIBC interface which shows stronger positive dipole potential weakens the negative surface potential,but its local weak binding to the isopropyl group facilitates hydrophobic interaction between Aβ42 and L-NIBC and resultedfiber aggregate.Conversely,electrostatic interaction between Aβ42 and D-NIBC induces spherical oligomer.Thesefindings provide new insight into molecular nature of chirality-regulated biological effect.
出处 《Aggregate》 EI CAS 2024年第5期454-464,共11页 聚集体(英文)
基金 National Key R&D Program of China,Grant/Award Number:2022YFE0113000 National Science Fund for Distinguished Young Scholars,Grant/Award Number:22025406。
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