2型糖尿病患者血清维生素D与血尿酸的相关性

Correlation between serum vitamin D and serum uric acid in patients with type 2 diabetes mellitus

目的 观察2型糖尿病患者血清维生素D水平和血尿酸水平的变化,并且探讨血清维生素D与血尿酸之间的相关性。方法 选取2023年1月至2023年6月于吉林大学中日联谊医院内分泌代谢科住院治疗的2型糖尿病患者587例为研究对象,测定其血清25(OH)D_(3)和血尿酸水平等指标。根据性别将2型糖尿病患者分为两组,根据血清25(OH)D_(3)水平分别将两组患者各分为3个亚组,分别比较各亚组患者中基本资料和生化指标。采用Spearman相关检验和多元线性回归分析评估血清25(OH)D_(3)与血尿酸之间的相关性。结果 在全部2型糖尿病患者中,维生素D缺乏的患者占67%,高尿酸血症的发生率为27.1%。在男性2型糖尿病患者中,血清25(OH)D_(3)与血尿酸之间呈负相关,这种关系在55岁以下患者、超重和肥胖患者以及肾功能正常的患者中比较明显。在多元线性回归分析中,未校正其他指标以及校正体质指数、肾小球滤过率后,血尿酸与血清25(OH)D_(3)之间呈负相关;校正体质指数、肾小球滤过率、年龄后,血尿酸与血清25(OH)D_(3)之间的相关性消失。在女性患者中,血清25(OH)D_(3)与血尿酸之间无显著相关性。结论 2型糖尿病患者血清维生素D水平普遍较低,高尿酸血症在2型糖尿病患者中发生率较高。在男性2型糖尿病患者中,血清25(OH)D_(3)与血尿酸之间呈负相关,但并非独立相关,且这种关系在55岁以下患者、超重和肥胖患者以及肾功能正常的患者中比较明显;在女性2型糖尿病患者中,血清25(OH)D_(3)与血尿酸之间无显著相关性。

Objective To observe the changes of serum vitamin D level and serum uric acid level in patients with type 2 diabetes mellitus, and to explore the correlation between serum vitamin D and serum uric acid.Methods A total of 587 patients with type 2 diabetes mellitus who were hospitalized in the Department of Endocrinology and Metabolism, China-Japan Union Hospital of Jilin University from January 2023 to June 2023 were selected as the study subjects, and their serum 25(OH)D_(3) and serum uric acid levels were measured.The patients were divided into two groups based on gender.Each group was further subdivided into three subgroups according to their serum 25(OH)D_(3) levels.The basic information and biochemical indicators of patients in each subgroup were compared.Spearman correlation analysis and multiple linear regression analysis were employed to assess the relationship between serum 25(OH)D_(3) and serum uric acid.Results Among all patients with type 2 diabetes, 67% were vitamin D deficient and the incidence of hyperuricemia was 27.1%.In male patients with type 2 diabetes, serum 25(OH)D_(3) was negatively correlated with serum uric acid, this relationship was more obvious in patients under 55 years old, overweight and obese patients, and patients with normal renal function.In multiple linear regression analysis, both unadjusted for other variables and adjusted for BMI and GFR,a negative correlation persisted between serum uric acid and 25(OH)D_(3).However, after adjusting for BMI,GFR and age, this correlation disappeared.In female patients, serum 25(OH)D_(3) was not significantly correlated with serum uric acid.Conclusion The serum vitamin D level was generally low in patients with type 2 diabetes.The incidence of hyperuricemia was relatively high among these individuals.In men with type 2 diabetes, serum 25(OH)D_(3) was negatively correlated with serum uric acid.However, this association was not independent.And it was more evident in patients under 55 years of age, overweight and obese patients, and patients with normal renal function.In women with type 2 diabetes, there was no significant correlation between serum 25(OH)D_(3) and serum uric acid.